Purines. XXI. Synthesis of Adenine 1-Oxides Carrying an Allylic Side Chain at the 9-Position
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概要
- 論文の詳細を見る
9-Allyladenine 1-oxide (3) has been prepared from 1-ethoxyadenine (6) in 58% overall yield through an unequivocal synthetic route. The route consists of an initial allylation of 6 with allyl bromide and Et-O bond cleavage of the resulting 9-allyl-1-ethoxyadenine hydrobromide (7) by treatment with boiling pyridine. Replacement of allyl bromide by 3-methyl-2-butenyl bromide in the above reaction sequence afforded 9-(3-methyl-2-butenyl) adenine 1-oxide (9) in 59% overall yield through the 1-ethoxy derivative 8.
- 公益社団法人日本薬学会の論文
- 1980-11-25
著者
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斎藤 徹
Faculty Of Pharmaceutical Sciences Kanazawa University
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井上 勲
Faculty Of Pharmaceutical Sciences Kanazawa University
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藤井 澄三
Faculty Of Pharmaceutical Sciences Kanazawa University
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板谷 泰助
Faculty of Pharmaceutical Sciences, Kanazawa University
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板谷 泰助
金沢大学薬学部
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Saito T
Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.
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