Modification by Fluoride, Bromide, Iodide, Thiocyanate and Nitrite Anions of Reaction of a Myeloperoxidase-H_2O_2-Cl^- System with Nucleosides
スポンサーリンク
概要
- 論文の詳細を見る
The influence of fluoride (F^-), bromide (Br^-), iodide (I^-), thiocyanate (SCN^-) and nitrite (NO^-_2) on the reaction of a myeloperoxidase-H2O2-CI^- system with a nucleoside mixture was studied. The reaction was carried outunder mildly acidic conditions and terminated by A-acetylcysteine. Without the additional anions, quantity of nucleosides consumed fell in the following order : 2'-deoxyguanosine>2'-deoxycytidine≫2'-deoxythymidine>2'-deoxyadenosine-0. F^- did not affect the reaction. Br^- increased the consumption of 2'-dcoxycytidine and 2'-deoxythymidine, but decreased that of 2'-deoxyguanosine. I^-, SCN^- and NO^-_2 suppressed the reaction. These results suggest that Br^- has a unique effect in relation to nucleoside damage caused by myeloperoxidase.
- 公益社団法人日本薬学会の論文
- 2003-03-01
著者
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斎藤 徹
Faculty Of Pharmaceutical Sciences Kanazawa University
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Suzuki T
Drug Discovery Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
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鈴木 徳治
千葉大 薬
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Suzuki T
Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
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Saito T
Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.
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Saito Takako
Research And Development Laboratories Maruho Co. Ltd.
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Suzuki Toshikazu
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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SUZUKI Toshinori
International Agency for Research on Cancer
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OHSHIMA Hiroshi
International Agency for Research on Cancer
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Suzuki T
Research Unit Of Pharmaceutics College Of Pharmacy Nihon University
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Sugihara T
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Saito T
Research And Development Laboratories Maruho Co. Ltd.
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