Purines. XLIV. : A Kinetic Study of the Dimroth Rearrangement of the Marine Sponge Purine 1,9-Dimethyl-8-oxoadenine and Related Compounds
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概要
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The reaction rates in the Dimroth rearrangements of the marine sponge base 1,9-dimethyl-8-oxoadenin (1) and related compounds such as 1,9-dimethyladenine (6a) and 8-bromo-1,9-dimethyladenine (6b) were measured in H_2O at various pH's and ionic strength 1.0 at 40℃. In all cases, attack of hydroxide ion on the protonated species of the substrate at the 2-position was faster than that on the neutral species by a factor of 100-1400. In the reaction of the protonated species, the relative ease of undergoing Dimroth rearrangement was in the order of 6b>6a>1. The same order of reactivity was found to hold for the neutral species.
- 公益社団法人日本薬学会の論文
- 1990-09-25
著者
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斎藤 徹
Faculty Of Pharmaceutical Sciences Kanazawa University
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藤井 澄三
Faculty Of Pharmaceutical Sciences Kanazawa University
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森 繁治
Faculty of Pharmaceutical Sciences, Kanazawa University
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森 繁治
Faculty Of Pharmaceutical Sciences Kanazawa University
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藤井 澄三
Shinshu Univ. Nagano Jpn
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