Laxative and Anti-diarrheal Activity of Polycarbophil in Mice and Rats
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the laxative and anti-diarrheal activity of polycarbophil, an insoluble hydrophilic polymer, in comparison with other agents used for treating functional bowel disorder (FBD). In naive rats, polycarbophil (500 mg/kg) increased fecal weight and water contents without producing diarrhea. Carboxymethylcellulose (CMC) did not produce evident changes in bowel movement. Picosulfate markedly produced diarrhea. Loperamide, trimebutine and granisetron decreased stool output dose-dependently. Constipation, indicated by decrease in fecal weight, was produced by loperamide and clonidine in rats. Polycarbophil (500 mg/kg) and CMC increased fecal weight without diarrhea. Conversely trimebutine further decreased fecal weight in constipated rats. Polycarbophil (500 mg/kg) suppressed diarrhea induced by castor oil, and at 250 – 500 mg/kg, it produced shaped stools in animals with stools loosened by prostaglandin E 2, serotonin or carbachol in mice. Polycarbophil (500 mg/kg) also reduced stools in rats with stool output increased by wrap restraint stress (WRS). CMC had no effect in the diarrhea models, except for carbachol-induced diarrhea, and WRS-induced evacuation. Loperamide, trimebutine and granisetron inhibited diarrhea production and WRS-induced evacuation, except for carbachol-induced diarrhea. The results show that polycarbophil prevents constipation and diarrhea without inducing diarrhea or constipation, which is different from the other agents. Hydrophilic polymers such as polycarbophil will be promising agents for the treatment of FBD.
- 社団法人 日本薬理学会の論文
- 2002-06-01
著者
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斎藤 徹
Faculty Of Pharmaceutical Sciences Kanazawa University
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Suzuki T
Drug Discovery Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
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Kato H
Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.
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Kato H
Teikyo Univ. Kanagawa Jpn
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Suzuki T
Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
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KATO Hideo
Research and Development Division, Hokuriku Seiyaku Co., Ltd.,
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SAITO Takaharu
Research and Development Headquarters, Hokurikit Seiyaku, Co., Ltd.
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MIZUTANI Fujie
Research and Development Headquarters, Hokurikit Seiyaku, Co., Ltd.
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IWANAGA Yuji
Research and Development Headquarters, Hokurikit Seiyaku, Co., Ltd.
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MORIKAWA Kouji
Research and Development Headquarters, Hokurikit Seiyaku, Co., Ltd.
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Saito T
Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.
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Saito Takako
Research And Development Laboratories Maruho Co. Ltd.
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Suzuki Toshikazu
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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Kato Hideo
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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Iwanaga Y
Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.
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Morikawa Kouji
Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.
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Mizutani Fujie
Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.
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Suzuki T
Research Unit Of Pharmaceutics College Of Pharmacy Nihon University
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Sugihara T
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Saito T
Research And Development Laboratories Maruho Co. Ltd.
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Iwanaga Yuji
Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.
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Kato Hideo
Yamaguchi Univ. Yamaguchi Jpn
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Morikawa Kouji
Research and Development Division, Hokuriku Seiyaku, Co., Ltd.
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Iwanaga Yuji
Research and Development Division, Hokuriku Seiyaku, Co., Ltd.
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