Synthesis of the Selective 5-Hydroxytryptamine 4 (5-HT_4) Receptor Agonist (+)-(S)-2-Chloro-5-methoxy-4-[5-(2-piperidylmethyl)-1,2,4-oxadiazol-3-yl]aniline
スポンサーリンク
概要
- 論文の詳細を見る
In a search for novel 5-hydroxytryptamine 4 (5-HT_4) agonists focusing on the linker group of benzamide derivatives, 2-chloro-5-methoxy-4-[5-(2-piperidylmethyl)-1,2,4-oxadiazol-3-yl]aniline (2) was prepared and its optical isomers were separated. The S isomer 2(S) showed high affinity for the human 5-HT_4 receptor without affinity for the human 5-HT_3 receptor, and potent 5-HT_4 agonistic activity in longitudinal muscle myenteric plexus (LMMP) preparations of guinea pig ileum. The R isomer 2(R) showed opposite selectivity. As a result of other receptor binding studies, 2(S) (YM-53389) was shown to be a highly selective 5-HT_4 agonist.
- 公益社団法人日本薬学会の論文
- 1999-01-15
著者
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斎藤 徹
Faculty Of Pharmaceutical Sciences Kanazawa University
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SUZUKI Takeshi
Institute for Solid State Physics, University of Tokyo
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Miyata K
Yamanouchi Pharmaceutical Co. Ltd. Ibaraki Jpn
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Miyata K
Yamanouchi Pharmaceutical Co. Ltd. Tsukuba City Jpn
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Miyata Keiji
Inflammation Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Suzuki T
Drug Discovery Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
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鈴木 徳治
千葉大 薬
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Suzuki T
Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
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Ohta Masato
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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Saito T
Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.
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Saito Takako
Research And Development Laboratories Maruho Co. Ltd.
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Suzuki Toshikazu
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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Ohta Miyako
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Miyata K
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co.
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Miyata K
Inflammation Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Nagakura Y
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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NAKAHARA Hideaki
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,
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MASE Toshiyasu
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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Suzuki T
Research Unit Of Pharmaceutics College Of Pharmacy Nihon University
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Sugihara T
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Saito T
Research And Development Laboratories Maruho Co. Ltd.
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Nakahara H
Graduate School Of Science And Engineering Saitama University
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IWAOKA Kiyoshi
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,
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IMANISHI Naoki
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,
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NAGAKURA Yukinori
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,
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MIYATA Kenji
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,
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OHTA Mitsuaki
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,
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Imanishi N
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Miyata K
Hitachi Research Laboratory Hitachi Ltd.
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Iwaoka Kiyoshi
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Mase T
Yamanouchi Pharmaceutical Co. Ltd. Ibaraki Jpn
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Nakahara Hideaki
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Suzuki Takeshi
Institute For Molecular And Cellular Regulation Gunma University
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