Biological Activity of Analogues of YM022. Novel (3-Amino Substituted Phenyl)urea Derivatives of 1,4-Benzodiazepin-2-one as Gastrin : Cholecystokinin-B Receptor Antagonists
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概要
- 論文の詳細を見る
A series of (3-substituted phenyl)urea analogues of the potent gastrin/cholecystokinin (CCK)-B receptor antagonist YM022 has been prepared. Structure-activity relationship studies of this series suggested that a number of analogues retained good in vitro potency for gastrin/CCK-B receptor. In particular, the (3-amino substituted phenyl)urea derivatives (10-12) were more potent inhibitors of pentagastrin-induced gastric acid secretion in rats than YM022 on intraduodenal (i.d.) administration.
- 公益社団法人日本薬学会の論文
- 1996-07-15
著者
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Miyata K
Yamanouchi Pharmaceutical Co. Ltd. Ibaraki Jpn
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Miyata K
Yamanouchi Pharmaceutical Co. Ltd. Tsukuba City Jpn
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Miyata Keiji
Inflammation Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Miyata Keiji
Neuroscience/gastrointestinal Research Laboratories Institute For Drug Discovery Research Yamanouchi
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Ohta Masato
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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NISHIDA Atsushi
Discovery and Pharmacology Research Laboratories, Tanabe Seiyaku Co., Ltd.
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Miyata Keiji
Neuroscience And Gastrointestinal Research Laboratory Institute For Drug Discovery Research Yamanouc
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Ohta Miyako
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Satoh Masato
Neuroscience
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Okamoto Yoshinori
Gastrointestinal Research Laboratories Institute For Drug Discovery Research Yamanouchi Pharmaceutic
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Miyata K
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co.
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KOSHIO Hiroyuki
Neuroscience
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OHTA Mitsuaki
Gastrointestinal Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceut
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NISHIDA Akito
Neuroscience
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AKUZAWA Shinobu
Gastrointestinal Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceut
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MASE Toshiyasu
Gastrointestinal Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceut
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SEMPLE Graeme
Neuroscience
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Akuzawa S
Yamanouchi Pharmaceutical Co. Ltd. Ibaraki Jpn
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Miyata K
Inflammation Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Nishida A
Discovery And Pharmacology Research Laboratories Tanabe Seiyaku Co. Ltd.
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Miyata K
Hitachi Research Laboratory Hitachi Ltd.
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Mase T
Yamanouchi Pharmaceutical Co. Ltd. Ibaraki Jpn
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Miyata Keiji
Neuroscience & Gastrointestinal Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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