YM-40461 Improves Airway Clearance in Guinea Pigs with Induced Subacute Bronchitis

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概要

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• The effects of the surfactant secretagogue YM-40461 on the mucociliary transport (MCT) velocity were examined in guinea pigs with induced bronchitis. Guinea pigs were exposed to SO_2 gas (900 ppm, 3 h/d) for 5 d. MCT velocity was measured by the movement of a 30% gelatin solution containing Evans blue dye placed on the tracheal mucosal surface. Repeated doses of YM-40461 improved the MCT guinea pigs with bronchitis within 5 d after the completion of SO_2 exposure, with an ED_<50> value of 3.1 mg/kg p.o. At a dose of 10 mg/kg p.o., YM-40461 restored MCT to the control level (98.0% recovery). Ambroxol, bromhexine and salbutamol also improved MCT, but were far less effective than YM-40461. Airway fluid collected from bronchitic animals revealed increased disaturated phosphatidylcholine (DSPC, a major component of surfactants)-to-protein ratio and decreased surface tension produced by YM-40461 treatment (10 mg/kg). These results suggest that YM-40461 ameliorates MCT dysfuction in animals with SO_2 gas-induced bronchitis by increasing the DSPC-to-protein ratio in the airway.

• 公益社団法人日本薬学会の論文
• 2000-12-01

著者

• Miyata K

  Yamanouchi Pharmaceutical Co. Ltd. Ibaraki Jpn

• Miyata K

  Yamanouchi Pharmaceutical Co. Ltd. Tsukuba City Jpn

• Miyata Keiji

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co.

• Miyata Keiji

  Inflammation Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha

• 富岡 清

  京都大学大学院薬学研究科

• YAMADA Tatsuhiko

  Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,

• Yamada T

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Miyata K

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co.

• Miyata K

  Inflammation Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha

• KIMOTO Aishi

  Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,

• HIRANO Yasuno

  Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,

• IWAI Takaya

  Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,

• SAITOU Munetoshi

  Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,

• TOMIOKA Kenichi

  Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,

• YAMADA Toshimitsu

  Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,

• SAITO Munetoshi

  Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co.

• Iwai T

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co.

• Kimoto Aishi

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co.

• Hirano Yasuno

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co.

• Tomioka K

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Saito M

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co.

• Yamada Takehisa

  Research And Development Division Hokuriku Seiyaku Co. Ltd.

• Miyata K

  Hitachi Research Laboratory Hitachi Ltd.

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