Application of Gel Formation for Taste Masking
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概要
- 論文の詳細を見る
Masking of the bitter taste from tablets by a water-insoluble gel formed by sodium alginate and bivalent metal was studied. Amiprilose hydrochloride was selected as the model drug with a bitter taste, and its core tablet was prepared. The core tablet was under-coated with sodium alginate and over-coated with calcium gluconate as a bivalent metal, or it was under-coated with calcium gluconate and over-coated with sodium alginate in order to form a gel on the surface of the tablet in the mouth at oral administration. The taste masking was evaluated by the amount of amiprilose hydrochloride released from the tablet. In addition, cross sections of the tablets subjected to a dissolution test were observed by scanning electron microscopy and energy dispersive X-ray microanalysis to evaluate the component distribution of the coated layers and behavior of the durg.Water-insoluble gel on the surface of the tablet was minimally formed by under-coating with sodium alginate and over-coating with calcium gluconate, and its masking time was 1min. On the other hand, water-insoluble gel was formed by under-coating with calcium gluconate and over-coating with sodium alginate, and its masking time was relatively long. These results suggest that the gel formation on the surface of tablets by under-coating with calcium gluconate and over-coating with sodium alginate is useful or taste masking of tablets in the mouth at the time of oral administration.
- 公益社団法人日本薬学会の論文
- 1997-06-15
著者
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齋藤 直樹
Meiji Pharmaceutical University
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林 弥生
College Of Pharmacy Kinjo Gakuin University
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Kanaya Y
Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac
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Kanaya Yoshio
Laboratory Of Medical And Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmacy
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Kanaya Yoshio
Tokyo University Of Pharmacy And Life Science
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Kanaya Yoshio
Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac
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YUASA Hiroshi
Laboratory of Medical and Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmac
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KANEKO Kaoru
Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,
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KANADA Ken
Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,
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MIYAGI Masaharu
Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,
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SAITO Noriyasu
Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,
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OZEKI Tetsuya
Laboratory of Medical & Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmacy
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YAMADA Tatsuhiko
Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,
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Yamada Tatsuhiko
Pharmaceutical Laboratories Kissei Pharmaceutical Co. Ltd.
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Kanada Ken
Pharmaceutical Laboratories Kissei Pharmaceuticalco. Ltd
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Kaneko K
Niigata College Of Pharmacy
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Ozeki Tetsuya
Department Of Pharmaceutics And Drug Delivery School Of Pharmacy Tokyo University Of Pharmacy And Li
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Yuasa H
Department Of Pharmaceutics And Drug Delivery School Of Pharmacy Tokyo University Of Pharmacy And Li
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Saito Noriyasu
Pharmaceutical Laboratories Kissei Pharmaceutical Co. Ltd.
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Yamada Takehisa
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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Yuasa Hiroaki
名古屋市立大学 薬研究薬剤学
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Yuasa Hiroshi
Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac
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Miyagi M
Kumamoto Inst. Technol. Kumamoto Jpn
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Miyagi Masaharu
Pharmaceutical Laboratories Kissei Pharmaceutical Co. Ltd.
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