A Facile Synthesis of 1,2,3,4-Tetrahydroisoquinolines through Cyclization of O, N-Acetals. II. : Syntheses of Isoquinolinequinone Antibiotics
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概要
- 論文の詳細を見る
A mild and effecient method for the synthesis of 1,2,3,4-tetrahydroisoquinolines 3a-c and 9 by a modified Pictet-Spengler reaction involving Lewis acid-mediated cyclization of the O, N-acetals 2a-c and 8 is described. The synthetic urility of this reaction is demonstrated with a preparation of two isoquinolinequinone antibiotics, renierone (11) and mimocin (12), from the ester 3c.
- 社団法人日本薬学会の論文
- 1989-06-25
著者
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齋藤 直樹
Meiji Pharmaceutical University
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久保 陽徳
明治薬科大学
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久保 陽徳
Meiji College of Pharmacy
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川上 南子
Meiji College of Pharmacy
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山田 恵理
Meiji College of Pharmacy
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Kubo Akinori
Graduate School Of Pharmaceutical Sciences Meiji Pharmaceutical University
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