In Vitro Release of Tranilast from Oily Gels and Penetration of the Drug into Yucatan Micropig Skin

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概要

• 論文の詳細を見る

• For the transdermal delivery of tranilast (TL), a drug used for the treatment of skin diseases such as keloids and hypertrophic scars, its oily gels were prepared; its in vitro release and penetration into Yucatan micropig skin were evaluated. In the gels that consisted of hydrogenated soybean phospholipids (HSL) and octyl isononanoate (IOIN), a fatty-acid ester, the release of TL from the gels was proportional to the drug content, and the extent of TL released up to 6 h from them was approximately 70% of the amount of applied TL. On the other hand, with the gels consisting of HSL and isocetyl isostearate (ICIS), the release of TL from the gels was about half of that from IOIN gels, even at the same drug concentration. When oily gels were used, the TL skin concentration was rapidly increased compared with the level obtained with suspensions. With 0.1% IOIN gel, a high concentration of TL (ca. 160 μg/g) in the dermis was obtained and continued until at least 48 h. These results suggest that oily gels may be useful for the topical application of TL.

• 公益社団法人日本薬学会の論文
• 1998-03-15

著者

• 齋藤 直樹

  Meiji Pharmaceutical University

• Matsumoto M

  Osaka Medical Center For Cancer And Cardiovascular Diseases Osaka

• Matsumoto Misako

  Department Of Immunology Osaka Medical Center For Cancer And Cardiovascular Diseases

• Fujii Makiko

  Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University

• Fujii M

  Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences

• Fujii Makiko

  Department Of Chemistry Faculty Of Engineering Gifu University

• Matsumoto Mitsuo

  Department of Pharmaceutics, Showa Pharmaceutical University

• MIYAGI Masaharu

  Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,

• SAITO Noriyasu

  Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,

• Fujii M

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• Matsumoto Mitsuharu

  Takeda Chemical Industries Ltd. Pharmaceutical Research Division

• Fujii M

  Showa Univ. Tokyo Jpn

• HORI Naohide

  Pharmaceutical Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• YAMANOUCHI Shizuka

  Department of Pharmaceutics, Showa College of Pharmaceutical Sciences

• Saito Noriyasu

  Pharmaceutical Laboratories Kissei Pharmaceutical Co. Ltd.

• Matsumoto Mitsuo

  Department Of Pharmaceutics Showa Pharmaceutical University

• Yamanouchi S

  Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences

• Hori N

  Pharmaceutical Research Laboratories Kissei Pharmaceutical Co. Ltd.

• Matsumoto Mitsuhiro

  First Department Of Internal Medicine Kumamoto University School Of Medicine

• HORI Noriyuki

  Kanebo Institute for Cancer Research, Kanebo, Ltd.,

• Matsumoto Mitsuo

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• Miyagi Masaharu

  Pharmaceutical Laboratories Kissei Pharmaceutical Co. Ltd.

• Matsumoto Mitsuo

  Department Of Ophthalmology Hirosaki University School Of Medicine

• Matsumoto Mitsuo

  Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University

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