A Practical Synthesis of the ABC Ring Model of Ecteinascidins

スポンサーリンク

概要

• 論文の詳細を見る

• A practical synthesis of 1,2,3,4,5,6-hexahydro-1,5-imino-10-hydroxy-9-methoxy-3,8,11-trimethyl-3-benzazocin-4-one (3) as an ABC ring model compound of ecteinascidin 743 and safracins from 3-hydroxy-4-methoxy-5-methylbenzaldehyde (7) is described. The overall yield in 15 steps is 27%.

• 社団法人日本薬学会の論文
• 2000-10-01

著者

• 齋藤 直樹

  Meiji Pharmaceutical University

• SAITO Naoki

  Meiji Pharmaceutical University

• KUBO Akinori

  Meiji Pharmaceutical University

• SEKI Ryu-ichi

  Meiji Pharmaceutical University

• TACHI Masashi

  Meiji Pharmaceutical University

• KAMAYACHI Hiroshi

  Meiji Pharmaceutical University

• Kubo A

  Meiji Pharmaceutical University

• Kubo Akinori

  Meiji College Of Pharmacy

• Tachi M

  Meiji Pharmaceutical University

• 久保 綾子

  Faculty Of Pharmaceutical Sciences Josai University

• Saito Naoki

  Meiji College Of Pharmacy

• Saito Norio

  Chemical Laboratory Meiji-gakuin University

関連論文

• An Acylated Cyanidin 3,7-diglucoside in the Bluish Flowers of Bletilla striata
• Triacylated Anthocyanidin 3-Arabinosylglucoside-7,3’-diglucosides Isolated from the Bluish Flowers of Tradescantia virginiana Cultivars and Their Distribution in the Tradescantieae
• Acylated Cyanidin 3-sophoroside-5-glucosides from the Purple Roots of Red Radish (Raphanus sativus L.) ‘Benikanmi’
• Chemistry of Renieramycins. Part 4. Synthesis of a Simple Natural Marine Product, 6-Hydroxy-7-methoxyisoquinolinemethanol
• Synthetic Approaches toward Ecteinascidins. Part 2. Preparation of the ABCDE Ring System of Ecteinascidins Having Characteristic Substituents in Both Benzene Rings
• Chemistry of Antitumor Isoquinolinequinone Alkaloids: Unexpected Oxidative Degradation of Saframycin S to Generate Simple Isoquinoline Alkaloids, Mimosamycin and Mimocin (Heterocycles 30th in Anniversary Issue)
• 13C NMR Spectral Assignment of 5-Hydroxy-1,5-imino-3-benzazocin-4,7,10-trione Derivatives: The Revised Structure of Renieramycin H
• 114(P-44) 海洋生物由来新規サフラマイシン系天然物の構造と合成研究(ポスター発表の部)
• A Practical Synthesis of the ABC Ring Model of Ecteinascidins
• 生体内酸化還元反応に関与する含窒素キノンの役割
• 10 サフラマイシン系抗生物質の合成研究 : 光学活性サフラマイシンMx2の全合成(口頭発表の部)
• Synthesis of Saframycins. X. Transformation of (-)-Saframycin A to (-)-Saframycin Mx Type Compound with the Structure Proposed for Saframycin E
• Synthesis of Saframycins. VIII. Synthesis of the ABC Ring of Safracins
• SYNTHESIS OF SAFRAMYCINS. VI. THE USEFUL TRANSFORMATION OF (-)-SAFRAMYCIN A TO (-)-SAFRAMYCIN Mx TYPE COMPOUND
• ちょっとした工夫から有用な反応が見つかる : 最近のDiels-Alder反応を例にとって
• 62 サフラマイシン系抗生物質の合成研究 : サフラマイシンCおよびDの合成(ポスター発表の部)
• SYNTHESIS OF SAFRAMYCINS. IV. : SELENIUM OXIDE OXIDATION OF 4-OXO-HEXAHYDRO-1,5-IMINO-3-BENZAZOCIN-7,10-DIONE; PROMISING METHOD TO CONSTRUCT SAFRAMYCINS C AND D FROM SAFRAMYCIN B
• 中員環を有するセスタテルペノイドの全合成
• A Facile Synthesis of 1,2,3,4-Tetrahydroisoquinolines through Cyclization of O, N-Acetals. II. : Syntheses of Isoquinolinequinone Antibiotics
• Synthssis of Saframycins. II. : Preparations and Reactions of N-Methyl-2,5-piperazinediones
• Preparations and Reactions of (Z)-3-Arylidene-6-arylmethyl-2,5-piperazinediones Having Highly Oxygenated Benzene Rings(Organic,Chemical)
• STRUCTURE OF SAFRAMYCIN D, A NEW DIMERIC ISOQUINOLINEQUINONE ANTIBIOTIC(Communications to the Editor)
• 60 サフラマイシンBの全合成研究
• A New Method for the Preparation of Michael Adducts and Cyclic Enones Using Lithium Chloride-Hexamethylphosphoramide System
• A New Synthesis of the Aporphine Alkaloids (±)-Glaucine and(±)-Nantenine. Application of [3C + 3C] Annelation to the D-Ring Formation
• 15(I-1) Renieramycins, the cytotoxic bistetrahydroisoquinoline alkaloids, from the Thai marine sponge, Xestospongia sp.
• Spontaneous Mutations of the Flavonoid 3'-hydroxylase Gene Conferring Reddish Flowers in the Three Morning Glory Species
• IDENTIFICATION OF THE MAGENTA MUTATIONS FOR FLOWER PIGMENTATION IN THE JAPANESE AND COMMON MORNING GLORIES
• The Gene Encoding Flavanone 3-Hydroxylase is Expressed Normally in the Pale Yellow Flowers of the Japanese Morning Glory Carrying the speckled Mutation Which Produce Neither Flavonol nor Anthocyanin but Accumulate Chalcone, Aurone and Flavanone
• In Vitro Inhalation Behavior of Spherically Agglomerated Steroid Particles with Carrier Lactose.
• PB91 SYNTHETIC APPROACHES TOWARD SAFRAMYCIN A
• Diacylated 8-C-Glucosylcyanidin 3-Glucoside from the Flowers of Tricyrtis formosana
• Formation of Water-Insoluble Gel in Dry-Coated Tablets for the Controlled Release of Theophylline
• Application of Gel Formation for Taste Masking
• An Acylated Pelargonidin 3-Sophoroside from the Pale-brownish Red Flowers of Ipomoea nii
• A Novel Acylated Pelargonidin 3-Sophoroside-5-glucoside from Greyish-Purple Flowers of the japanese Morning Glory
• Acylated Pelargonidin 3-Sophoroside-5-glucosides from the Flowers of the Japanese Morning Glory Cultivar 'Violet'
• New diacylated delphinidin 3-rutinoside-5-glucosides isolated from the blue-purple flowers of Browallia speciosa
• Four acylated cyanidin 3-sambubioside-5-glucosides from the purple-violet flowers of lobularia maritima
• Genes Encoding the Vacuolar Na^+/H^+ Exchanger and Flower Coloration
• THE Pr (Purple) GENE OF THE JAPANESE MORNING GLORY CONTROLLING BLUE COLORATION OF FLOWER LIMB ENCODES THE Na^+/H^+ EXCHANGER
• スタートライン : 薬学教育・新しい大学院博士前期(修士)課程
• Effect of Tranilast Oily Gel on Carrageenin-Induced Granulation in Rats
• Effect of UV-Absorbing Agents on Photodegradation of Tranilast in Oily Gels
• In Vitro Release of Tranilast from Oily Gels and Penetration of the Drug into Yucatan Micropig Skin
• Acylated Cyanidin 3,7,3'-Triglucosides with p-Hydroxybenzoic Acid from the Flowers of Dendrobium
• Application of Carbopol^ to Controlled Release Preparations. II. Controlled Release by Use of Carbopol^ as a Matrix Material, as a Coating Material, and as Both
• In vitro inhalation behavior of spherically agglomerated steroid particles with carrier lactose
• Synthesis of Novel Octahydro-1,5-imino-3-benzazocin-4,7,10-trione Derivatives Having a Methyl Group at the C-2 Position as ABC Ring Models of Saframycins
• Synthesis of 5,8- and 5,6-Quinolinediones Using Oxidative Demethylation with Cerium(IV) Ammonium Nitrate
• Flower Colors and their Anthocyanins in Matthiola incana Cultivars (Brassicaceae)
• FLORAL PIGMENTS ISOLATED FROM THE SKY-BLUE FLOWERS OF OXYPETALUM CAERULEUM
• Studies on flower color in Chrysanthemum morifolium RAMAT. I. Anthocyanins
• The crystal and molecular structures of esculetin 6-glucoside and 7-glucoside.
• The crystal and molecular structure of daphnetin 8-.BETA.-D-glucopyranoside dihydrate isolated from Daphne odora.

もっと見る 閉じる

スポンサーリンク