Synthesis of Saframycins. X. Transformation of (-)-Saframycin A to (-)-Saframycin Mx Type Compound with the Structure Proposed for Saframycin E
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概要
- 論文の詳細を見る
Treatment of (-)-saframycin A (1a) with selenium oxide in acetic acid afforded (-)-saframycin G (1g), and a catalytic reduction and regionselective oxidation sequence afforded the saframycin Mx type compound (3). We applied this methodology to the transformation of (±)-5-hydroxysaframycin B (11) to the hydroquinone (1e). Acetylation of 1e with acetic anhydride in pyridine gave the triacetate (13), which is identical with the triacetyl derivative of natural saframycin E.
- 社団法人日本薬学会の論文
- 1995-05-15
著者
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齋藤 直樹
Meiji Pharmaceutical University
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久保 陽徳
明治薬科大学
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原田 俊司
Meiji College of Pharmacy
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西田 昌代
Meiji College of Pharmacy
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井上 泉
Meiji College of Pharmacy
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久保 陽徳
Meiji College of Pharmacy
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Nishida Makiko
崇城大学 薬学部薬学科
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Nishida M
Department Of Clinical Pharmacy Faculty Of Pharmacy Meijo University
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Kubo Akinori
Graduate School Of Pharmaceutical Sciences Meiji Pharmaceutical University
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NISHIDA Miharu
Department of Analytical Chemistry of Medicines, Showa Pharmaceutical University
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