Inhibition of Avian Myeloblastosis Virus Reverse Transcriptase by Heterocyclic Quinones : Structure-Activity Correlation
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概要
- 論文の詳細を見る
Synthetic heterocyclic quinones (107 samples) consisting of o- and p-quinoline quinones, o-isoquinoline quinones and p-quinoxaline quinones as well as o- and p-naphthoquinones (3 samples) were tested for their inhibitory activities against avian myeloblastosis virus reverse transcriptase (AMV-RT) and cytotoxic activities against mouse lymphoblastoma L5178Y cells. In general, o-quinoline quinones (i.e., the 5,6-quinolinedione derivatives) are more potent inhibitors of AMV-RT than p-quinoline quinones (the 5,8-quinolinedione derivatives). Furthermore, the growth of L5178/Y cells were significantly refractory to the 8-methoxy-5,6-quinolinedione derivatives whose suppressive effects on AMV-RT function were fairly comparable to those of the other o-quinoline quinones. The longer the chain length of 7-alkyl substituent in o- or p-quinoline quinones, the lower the biological activities.
- 公益社団法人日本薬学会の論文
- 1991-04-25
著者
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久保 陽徳
明治薬科大学
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北原 嘉泰
明治薬科大学
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中村 昭四郎
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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井上 義雄
科学警察研究所
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Inouye Y
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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井上 義雄
広島大学医学部
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井上 義雄
Institute of Pharmaceutical Science Hiroshima University School of Medicine
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Kubo Akinori
Graduate School Of Pharmaceutical Sciences Meiji Pharmaceutical University
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松本 秀美
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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森重 隆次
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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北原 嘉泰
Department of Organic Chemistry, Meiji College of Pharmacy
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久保 陽徳
Department of Organic Chemistry, Meiji College of Pharmacy
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松本 秀美
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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森重 隆次
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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中村 昭四郎
Institute Of Pharmaceutical Sciences
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中村 昭四郎
Institute Of Applied Microbiology University Of Tokyo
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