55 新抗生物質Saframycin A,B,Cの構造

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概要

• 論文の詳細を見る

• In the course of screening for new antibiotics which are active against established cell line of L1210 mouse leukemia, we found that a strain of Streptomyces lavendulae, designated as No 314, exhibited cytotoxicity to the line of tumor in addition to the production of streptothricin. Satellite antibiotics named mimosamycin and saframycin A to E have been obtained from the organic solvent extract of the cultured filtrate. In these antibiotics, the structure of mimosamycin[C_<12>H_<11>NO_4] was determined as formula 1. In this report structural elucidation of saframycin A, B and C and the antitumor activity of saframycin A will be discussed. ^<13>C NMR and mass spectral data of saframycin A, B and C indicated that these antibiotics have the same carbon skeleton; dimeric structures of mimosamycin(1). The structure of saframycin C[C_<29>-H_<33>N_3O_9] was established by an X-ray crystallographic study of its hydrobromide. From these results, the structures of saframycin B [C_<28>H_<31>N_3O_8] and A[C_<29>H_<30>N_4O_8] were determined as 14-desmethoxy-saframycin C and 21-cyanosaframycin B, respectively. Saframycin B, C and A therefore have the structures depicted in 3, 4 and 8 or their antipodes.

• 天然有機化合物討論会の論文
• 1979-09-20

著者

• 久保 陽徳

  明治薬大薬

• 久保 陽徳

  明治薬科大学

• 高橋 勝弘

  Department of Antibiotics, Research Institute for Chemobiodynamics, Chiba University

• 新井 正

  Department of Antibiotics, Research Institute for Chemobiodynamics, Chiba University

• 高橋 勝弘

  Department Of Antibiotics Research Institute For Chemobiodynamics Chiba University

• 新井 正

  Department Of Antibiotics Research Institute For Chemobiodynamics Chiba University

• 中原 伸輔

  Meiji College of Pharmacy

• 新井 正

  千葉大・生物活性研

• 高橋 勝弘

  千葉県がんセンター研

• 中原 伸輔

  明治薬大

• 田村 千尋

  三共中研

• Kubo Akinori

  Graduate School Of Pharmaceutical Sciences Meiji Pharmaceutical University

• 田村 千尋

  Analytical And Metabolic Research Laboratories : Sankyo Company Ltd.

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