Structure Elucidation of the Bioactive Metabolites of ML-236B (Mevastatin) Isolated from Dog Urine

スポンサーリンク

概要

論文の詳細を見る
Two active metabolites of ML-236B, 4β, 6α-dihydroxy ML-236B (M3,2), and 3β-hydroxy ML-236B (M4,3), were isolated from the urine of ML-236B-treated dogs. The structures of M3 and M4 were elucidated on the basis of spectral data and confirmed by X-ray analysis.
社団法人日本薬学会の論文
1986-04-25

著者

関連論文

Chaetoglobosins, Cytotoxic 10-(Indol-3-yl)-[13] cytochalasans from Chaetomium spp. III. Structures of Chaetoglobosins C, E, F, G, and J
Chaetoglobosins, Cytotoxic 10-(Indo-3-yl)-[13] cytochalasans from Chaetomium spp. II. Structures of Chaetoglobosins A, B, and D
52 Chaetomium globosumの代謝する細胞毒性物貭Chaetoglobosin A-Fの構造
Studies of Human Immunodeficiency Virus Type 1 (HIV-1) Protease Inhibitors. III. Structure-Activity Relationship of HIV-1 Protease Inhibitors Containing Cyclohexylalanylalanine Hydroxyethylene Dipeptide Isostere
Studies of HIV-1 Protease Inhibitors. II.Incorporation of Four Types of Hydroxyethylene Dipeptide Isosteres at the Scissile Site of Substrate Sequences
Studies of HIV-1 Protease Inhibitors. I.Incorporation of a Reduced Peptide, Simple Aminoalcohol, and Statine Analog at the Scissile Site Substrate Sequences
Structure Elucidation of the Bioactive Metabolites of ML-236B (Mevastatin) Isolated from Dog Urine
Conformational Study of 3,4-Epiminopyrrolidines in Solution
Studies on Indole Derivatives. XV. Synthesis of Indoxyl Derivatives. (1). Crystal and Molecular Structure of Anhydro-2-benzyl-1-mercapto-3-methyl-9-oxo-(9H)-imidazo[1,5-α]indolium Hydroxide
304. グルタミン酸脱炭酸酵素阻害剤 4,5-dihydroxyisophthalic acid の分離と阻害作用
61 γ-Aminobutyrate Aminotransferase Inhibitor : Gabaculineの構造と合成
38 Herbicidin A,Bの構造
Studies on Hindered Phenols and Analogues. V. Synthesis, Identification, and Antidiabetic Activity of the Glucuronide of CS-045
47(P03) 三置換オレフィンの立体選択的構築を鍵反応とした生理活性を有するジテルペン類の全合成(ポスター発表の部)
Cycloleonurinin, a Cyclic Peptide from Leonuri Fructus
Chetracin A and Chaetocins B and C, Three New Epipolythiodioxo-piperazines from Chaetomium spp.
12 新規IV型コラゲナーゼ阻害剤、matlystatin類に関する研究(口頭発表の部)
1,2,4-チアジアゾリジン誘導体の研究-3-1,2,4-チアジアゾリジン誘導体の異性体の陰イオン質量スペクトル
90 海生菌Phoma sp.の生産するPAF拮抗物質phomactin類の構造(口頭発表の部)
55 新抗生物質Saframycin A,B,Cの構造
Stereospecific Taurine Conjugation of the trans-OH Metabolite (Active Metabolite) of CS-670,a New 2-Arylpropionic Acid Nonsteroidal Anti-inflammatory Drug, in Dogs
Studies on Quinolizinium Salts. IX. Ring-Opening Reactions of Benzo [α]-and Benzo [c] quinolizinium Bromides with a Grignard Reagent and Geometrical Determinations of the Resultant Butadienes
REACTION OF 5,13-DI-TERT-BUTYL-8,16-DIMETHYL [2. 2] METACYCLOPHAN-1-ENE WITH DICHLOROCARBENE
41 MILBEMYCIN α1,2,3,4,5,6,7,8,9,10およびβ1の構造
2 いわなんてん(Leucothoe Keiskei Mig.)の成分研究
Studies on Benzodiazepinooxazoles. II. Crystal and Molecular Structure of 10-Bromo-2,3,5,6,7,11b-hexahydro-2-methyl-11b-phenylbenzo [6,7]-1,4-diazepino [5,4-b] oxazol-6-one, C_H_O_2N_2Br・C_2H_5OH
Studies on the Constituents of Lespedeza homoloba NAKAI. III. The Structures of Lespein and Lespedezin
16 シグナルペプチダーゼII阻害剤グロボマイシンの構造決定と不斉全合成(口頭発表の部)
70 Croton sublyratusより得た抗Shay潰瘍性フラノジテルペン
A Quantitative Analysis of Proton Nuclear Magnetic Relaxation : Conformation Analysis of Substituted 5,1-Benzothiazocine and Its Homologue(Organic,Chemical)
Studies on Seven-membered Ring Compounds. XXXVII. The Reaction of Benzotropones with Malononitrile
Use of a Shift Reagent in First-Order Analysis of Cyclopropane Derivatives in NMR Spectroscopy
Isolation and Structure of Antipeptic Ulcer Diterpene from Thai Medicinal Plant
The Structure of Toxic Components from Leucothoe Keiskei
Proton Nuclear Magnetic Relaxation : An Application to the Study of the Conformation and Configuration of Saframycin A
Novel Diterpenelactones with Anti-peptic Ulcer Activity from Croton sublyratus
Studies on Griseolic Acid Derivatives. VII. : Synthesis and Phosphodiesterase Inhibitory Activity of the C^-C^ Hydrogenated Products of Griseolic Acid and Their Base-Exchanged Derivatives
7 Amaromycinの構造について
A Quantitative Analysis of Nuclear Magnetic Relaxation : The Configuration and the Conformation of ML-236B(Mevastatin) Metabolites(Organic,Chemical)
Studies on the Constituents of Desmodium caudatum DC.

もっと見る

スポンサーリンク