Studies on Hindered Phenols and Analogues. V. Synthesis, Identification, and Antidiabetic Activity of the Glucuronide of CS-045
スポンサーリンク
概要
- 論文の詳細を見る
The glucoronide of a new oral antidiabetic agent, (±)-5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl]thiazolidine-2,4-dione (CS-045) (1), was synthesized to confirm the stracture of a metabolite in monkeys (Macacafascicularis) and to examine its antidiabetic activity. The glucuronide also had antidiabetic activity in KK-mice.
- 社団法人日本薬学会の論文
- 1991-08-25
著者
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藤田 岳
三共株式会社化学研究所
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桑野 晴光
Analytical and Metabolic Research Laboratories
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木下 武
Analytical and Metabolic Research Laboratories
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中村 皖一
三共USA
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木下 武
三共株式会社 分析代謝研究所
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吉岡 孝雄
(株)ケムテックラボ
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吉岡 孝雄
Medicinal Chemistry Research Laboratories
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相澤 有一
Medicinal Chemistry Research Laboratories
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藤田 岳
Medicinal Chemistry Research Laboratories
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中村 皖一
Analytical and Metabolic Research Laboratories
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笹原 邦宏
Product Development Laboratories
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堀越 大能
Biological Research Laboratories, Sankyo Co., Ltd.,
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木下 武
三共(株)分析代謝研究所
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木下 武
Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
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堀越 大能
Biological Research Laboratories Sankyo Co. Ltd.
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