抗酸化作用を有する薬物の研究 : 抗糖尿病薬, トログリタゾン(CS-045)の開発

スポンサーリンク

概要

• 論文の詳細を見る

• An interest in compounds having both the quenching activity of the active oxygen species (antioxidant activity) and hypoglycemic and/or hypolipidemic activities significantly increases in the field of angiopathic disease, especially in the elderly. We studied hindered phenols in order to find biologically active compounds having the above activities. As a result, several compounds, such as 1,3-benzoxathioles, phenoxypentanoic acids, phenoxypentanols, 2-chloro-3-phe-nylpropionic acids, and thiazolidines, were found. Among these compounds, a thiazolidine, troglitazone, (CS-045), 1,showed desired biological properties both in vitro and in vivo without causing any increase in liver weight, and so was developed as a new type of antidiabetic agent. In this review, the structural design and the biological activities including antioxidant activities are described.

• 社団法人日本薬学会の論文
• 1997-09-25

著者

• 藤田 岳

  三共株式会社化学研究所

• 吉岡 孝雄

  (株)ケムテックラボ

• 吉岡 孝雄

  株式会社ケムテックラボ

関連論文

• Studies on Hindered Phenols and Analogues. V. Synthesis, Identification, and Antidiabetic Activity of the Glucuronide of CS-045
• ノスカールの開発裏話
• 抗酸化作用を有する薬物の研究 : 抗糖尿病薬, トログリタゾン(CS-045)の開発

スポンサーリンク