Conformational Study of 3,4-Epiminopyrrolidines in Solution
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概要
- 論文の詳細を見る
The NOE's of the pyrrolidine ring protons, H_A and H_B, on the phenyl ring protons of the N-substituent, H_D, were determined in 1-(p-methoxyphenyl)-3,4-epiminopyrrolidine (2), its N-benzyl derivative (1), and its N-acetate (12). Notable differences of NOE's observed in the latter two compounds suggested that the p-methoxyphenyl group is preferentially situated on the same side as the cis-fused aziridine ring in these compounds. Synthesis of some 3,4-epiminopyrrolidines was also reported in connection with this NOE study.
- 社団法人日本薬学会の論文
- 1970-12-25
著者
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大木 英二
Central Research Laboratories, Sankyo Co., Ltd.
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老田 貞夫
Central Research Laboratories, Sankyo Co., Ltd.
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大橋 芳彦
Central Research Laboratories, Sankyo Co., Ltd.
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桑野 晴光
Central Research Laboratories, Sankyo Co., Ltd.
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桑野 晴光
Analytical and Metabolic Research Laboratories
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大橋 芳彦
Central Research Laboratories Sankyo Co. Ltd.
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大木 英二
Research Laboratory Zenyaku Kogyo Co. Ltd.
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大木 英二
Central Research Laboratories Sankyo Co. Ltd.
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老田 貞夫
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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