Synthesis of 3', 4'-Dideoxybutirosin A, Active against Butirosin Resistant Bacteria
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概要
- 論文の詳細を見る
In order to overcome butirosin-resistant microorganisms of 3'-O-phosphorylation type, 3', 4'-dideoxybutirosin A (2) was synthesized according to the method of Umezawa, et al. The synthesized 3', 4'-dideoxy derivative (2) exhibited significant activities agaisnt both butirosin-sensitive and resistant strains in vitro and in vivo and its acute toxicity was found to be at a similar level to that of butirosin.
- 社団法人日本薬学会の論文
- 1974-05-25
著者
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大木 英二
Central Research Laboratories, Sankyo Co., Ltd.
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大橋 芳彦
Central Research Laboratories, Sankyo Co., Ltd.
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大橋 芳彦
Central Research Laboratories Sankyo Co. Ltd.
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佐伯 博道
Central Research Laboratories, Sankyo Co., Ltd.
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島田 芳和
Central Research Laboratories, Sankyo Co., Ltd.
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田島 政三
Central Research Laboratories, Sankyo Co., Ltd.
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菅原 眞一
Central Research Laboratories, Sankyo Co., Ltd.
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大木 英二
Research Laboratory Zenyaku Kogyo Co. Ltd.
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大木 英二
Central Research Laboratories Sankyo Co. Ltd.
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菅原 眞一
Central Research Laboratories Sankyo Co. Ltd.
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島田 芳和
Central Research Laboratories Sankyo Co. Ltd.
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佐伯 博道
Central Research Laboratories Sankyo Co. Ltd.
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