An Alternate Synthesis of Leupeptins and Their Analogs
スポンサーリンク
概要
- 論文の詳細を見る
It was found that lithium aluminum hydride reduction of N^a, N^G-disubstituted arginine lactam (3a-c) at a low temperature gave a corresponding argininal derivative (4a-c). Analogous reduction of acetyl-L-leucyl-L-leucyl-N-benzyloxycarbonyl-L-arginine lactam (8b) or its dipeptide analog (13) yielded leupeptin Ac-LL(1a) or acetylleucyl-argininal (11) respectively. Antiplasmin activities of these synthetic leupeptins were also reported.
- 公益社団法人日本薬学会の論文
- 1973-01-25
著者
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梅沢 浜夫
微化研
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大木 英二
Central Research Laboratories, Sankyo Co., Ltd.
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梅沢 浜夫
Institute of Microbial Chemistry
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前田 謙二
微化研
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佐伯 博道
Central Research Laboratories, Sankyo Co., Ltd.
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島田 芳和
Central Research Laboratories, Sankyo Co., Ltd.
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大木 英二
Research Laboratory Zenyaku Kogyo Co. Ltd.
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大木 英二
Central Research Laboratories Sankyo Co. Ltd.
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島田 芳和
Central Research Laboratories Sankyo Co. Ltd.
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佐伯 博道
Central Research Laboratories Sankyo Co. Ltd.
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