Streptomyces kasugaensisによるカスガマイシンの生産 : (第2報)^<14>C-脂肪酸のカスガマイシンへのとりこみ

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The biosynthesis of kasugamycin in Streptomyces kasugaensis has been studiedby adding ^<14>C-fatty acid to the growth medium and degrading the kasugamycin produced. The incorporation rate of radio-activity from ^<14>C-fatty acid into kasugamycin was from 2 to 4 percent. The degradation of the isolated kasugamycin disclosed that the ^< : 14>C was located uniformly in the d-inositol, kasugamine and amidine carboxylate portions of the molecule. Experiments with other labelled compounds distinctly suggested that d-inositol and kasugamine are derived from myoinositol and glucosamine respectively.The increase in kasugamycin production in media containing fatty acids or fatty acid esters as the carbon source was suggested to be due to the utilization of fatty acid carbons for all carbons of kasugamycin and to the gradual utilization of fatty acids or their esters which remain throughout the fermentation period.
社団法人日本生物工学会の論文
1971-02-25