32 ヌクレオシド抗生物質オキザノシンの構造と全合成

概要

論文の詳細を見る
Oxanosine is a novel nucleoside antibiotic produced by Streptomyces capreolus MG265-CF3. It is not only active against Escherichia coli K-12, Shigella sp. and Proteus sp. in peptone medium, but also inhibits the growth of leukemia L-1210 cells and prolongs the life span of tumor bearing mice. Recently, it has been noticed that formation of suppressor cells is suppressed and activity of macrophage is stimulated by oxanosine. The structure of oxanosine was elucidated to be 5-Amino-3-β-D-ribofuranosyl-3H-imidazo [4,5-d][1,3] oxazin-7-one by physicochemical data and X-ray crystallography. On the basis of chemical interconversion (scheme 1), the synthesis of oxanosine was achieved from readily available compound 4 via 5 steps. Synthesis and biological activities of 2'-deoxyoxanosine, which is derived from oxanosine, are also reported.
天然有機化合物討論会の論文
1983-09-15