82(P2-12) 放線菌の生産する新規テルペンアルカロイド、アルテミシジンの構造(ポスター発表の部)

概要

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Screening of new insecticidal and acaricidal antibiotics was carried out with reference to anti-brine shrimp activity from actinomycete strains. As a result, one actinomycete isolates identified as Streptomyces sioyaensis SA-1758 was found to produce a new substance, altemicidin. Altemicidin was purified by activated charcoal, Diaion CHP-20P and Sephadex LH-20 column chromatographies. The molecular formula was determined as C_<13>H_<20>N_4O_7S by elemental analysis, mass spectra and ^<13>C NMR spectrum. The structure was determined to be (1R,2S,3aR,7aS)-4-carbamoy1-2-hydroxy-6-methyl-1-(sulfamoylacetamido)-2,3,3a,6,7,7a-hexahydro-6-azaindene-1-carboxylic acid by the spectroscopic analysis and X-ray crystallographic analysis of its derivatives. Altemicidin belongs to the monoterpene alkaloid. Altemicidin showed not only acaricidal activity but also antitumor activity. And the compound showed no antimicrobial activity.
天然有機化合物討論会の論文
1989-09-17