16 Eurycoma longifolia より得られた新規スクワレン型トリテルペンエーテル及びカッシノイドに関する研究(口頭発表の部)
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概要
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The crude extract of Eurycoma longifolia Jack (Simaroubaceae) has long been used as one of traditional folk medicines in the Southeast Asia. During the survey of cytotoxic antitumor compounds from the title plant, three novel cytotoxic squalene-type triterpene ethers, named eurylene (1), 14-deacetyl eurylene (2) and longilene peroxide (3), and 14 novel quassinoids were isolated from the woods together with teurilene (4). Their structure were elucidated by spectroscopic data, chemical evidence and X-ray analysis. The absolute stereostructure of 1 was determined by an advanced Mosher's method. Molecular conformation of 1 with linear form was different from those of 3 and 4 with a turn structure. Conformational analysis of 2 showed that 2 possess the similar turn structure with an intramolecular hydrogen bonding to 3 and 4. The new skeleton C_<19>-type quassinoids, named as longilactone and 6-dehydroxylongilactone, were found to form a lactonic linkage at C-7 and many C_<20>-type quassinoids were isolated. These structures were elucidated by spectroscopic methods and X-ray analysis. The cytotoxic activities of these squalene-type triterpene ethers and quassinoids are also discussed.
- 天然有機化合物討論会の論文
- 1992-09-10
著者
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飯高 洋一
帝京大・医
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森田 博史
Department Of Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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竹谷 孝一
東京都立衛生研究所
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岸 悦子
Department Of Pharmacognosy Tokyo College Of Pharmacy
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糸川 秀治
東京薬科大学 薬学部
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森田 博史
東京薬科大学
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飯高 洋一
西東京大・理工
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糸川 秀治
東薬大
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森田 博史
東薬大
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竹谷 孝一
東薬大
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岸 悦子
東薬大
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