79 南米産Maytenus属生薬より得られたトリテルペンダイマーおよびセスキテルペンポリエステルの構造(ポスター発表の部)
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概要
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During our studies on biologically active compounds in South American medicinal plants, we were interested in plants of the genus Maytenus, widely used as folk medicines. In this work, three medicinal plants belonged to Maytenus species were examined. From M. ilicifolia, which called "cangorosa" in Paraguay, four triterpene dimers (4-7), ten oligo-nicotinated sesquiterpene polyesters (8-17), three macrocyclic sesquiterpene pyridine alkaloids (18-20) and three other compounds were isolated. From M. ebenifolia, named "chuchuhuasi", which is used as for the treatments of rheumatism in Peru, twelve macrocyclic sesquiterpene pyridine alkaloids (21-33) were isolated. Then from M. chuchuhuasca, obtained as "xuxua" at Brazil, used for the treatment of skin cancer, four triterpene dimers (35-38), two macrocyclic sesquiterpene pyridine alkaloids (40, 41), along with an aromatic triterpene (34) were isolated. These structures were determined by means of ^1H and ^<13>C NMR spectroscopic studies mainly 2D experiments, MS, IR, UV and CD spectra. Triterpene dimers, which have cytotoxic activities against tumor cell lines, were characteristic components of these plants, and were consisted of pristimerin or tingenone type quinoid-triterpenes, and two of them were related to be atropisomer separated by a barrier of 32.8kcal/mol. Oligo-nicotinated sesquiterpene polyesters contained two or three nicotinyl groups in dihydroagarofuran skeleton. Macrocyclic sesquiterpene pyridine alkaloids possess either a fifteen- or sixteen-membered ring structure in their molecule, and the flexibilities of these ring systems were evaluated by measuring the spin-lattice relaxation time, T_1, by ^<13>C NMR spectroscopy.
- 天然有機化合物討論会の論文
- 1993-09-10
著者
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糸川 秀治
東京薬大
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森田 博史
Department Of Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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竹谷 孝一
東京都立衛生研究所
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代田 修
徳島文理香川薬
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竹谷 孝一
東京薬大薬
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糸川 秀治
東京薬科大学 薬学部
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森田 博史
東京薬科大学
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飯高 洋一
西東京大・理工
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森田 博史
東京薬大薬
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森田 博史
東京薬大、薬
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竹谷 孝一
東京薬大、薬
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代田 修
東京薬大
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