CONFORMATIONAL ANALYSIS OF [N-DEMETHYL-TYR(OCH_3)-3]RA-VII, CONFORMATIONALLY RESTRICTED MODEL APPROACH
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概要
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A molecular design was carried out in a way that locked the type II β-turn conformation of RA-VII, which was isolated from Rubia cordifolia and R.akane, by removing the N-methyl group of the Tyr-3 residue. Conformational analysis of [N-Demethyl-Tyr(OCH_3)-3]RA-VII, derived from RA-VII by hepatic microsomal biotransformation, was conducted by 2D-NMR techniques, temperature effect on NH protons, and NOE experiments. It showed a restricted conformational state with a typical type II β-turn structure between Ala-2 and Tyr-3 in solution.
- 公益社団法人日本薬学会の論文
- 1991-08-25
著者
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森田 博史
Department of Pharmacognosy, Tokyo College of Pharmacy
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竹谷 孝一
Department of Pharmacognosy, Tokyo College of Pharmacy
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糸川 秀治
Department of Pharmacognosy, Tokyo College of Pharmacy
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森田 博史
Department Of Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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竹谷 孝一
東京都立衛生研究所
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糸川 秀治
東京薬科大学 薬学部
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森田 博史
東京薬科大学
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斉藤 敬子
Department Of Pharmacognosy Tokyo College Of Pharmacy
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