CONFORMATIONAL ANALYSIS OF [N-DEMETHYL-TYR(OCH_3)-3]RA-VII, CONFORMATIONALLY RESTRICTED MODEL APPROACH

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概要

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• A molecular design was carried out in a way that locked the type II β-turn conformation of RA-VII, which was isolated from Rubia cordifolia and R.akane, by removing the N-methyl group of the Tyr-3 residue. Conformational analysis of [N-Demethyl-Tyr(OCH_3)-3]RA-VII, derived from RA-VII by hepatic microsomal biotransformation, was conducted by 2D-NMR techniques, temperature effect on NH protons, and NOE experiments. It showed a restricted conformational state with a typical type II β-turn structure between Ala-2 and Tyr-3 in solution.

• 公益社団法人日本薬学会の論文
• 1991-08-25

著者

• 森田 博史

  Department of Pharmacognosy, Tokyo College of Pharmacy

• 竹谷 孝一

  Department of Pharmacognosy, Tokyo College of Pharmacy

• 糸川 秀治

  Department of Pharmacognosy, Tokyo College of Pharmacy

• 森田 博史

  Department Of Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences

• 竹谷 孝一

  東京都立衛生研究所

• 糸川 秀治

  東京薬科大学 薬学部

• 森田 博史

  東京薬科大学

• 斉藤 敬子

  Department Of Pharmacognosy Tokyo College Of Pharmacy

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