Solution Forms of Antitumor Cyclic Pentapeptides with 3,4-Dichlorinated Proline Residues, Astins A and C, from Aster tataricus
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概要
- 論文の詳細を見る
Conformational analysis of antitumor cyclic pentapeptides, astins A (1) and C (3), was made by a combination of NMR and computational techniques. These results indicated that the backbone conformations of 1 and 3,with lower activity than astin B (2), were different from that of 2. The backbone conformation together with a cis 3,4-dichlorinated proline residue was considered to play an important role in the antitumor activities of astins.
- 公益社団法人日本薬学会の論文
- 1995-08-15
著者
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森田 博史
Department of Pharmacognosy, Tokyo College of Pharmacy
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竹谷 孝一
Department of Pharmacognosy, Tokyo College of Pharmacy
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糸川 秀治
Department of Pharmacognosy, Tokyo College of Pharmacy
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森田 博史
Department Of Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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竹谷 孝一
東京都立衛生研究所
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竹谷 孝一
東京薬大薬
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糸川 秀治
東京薬科大学 薬学部
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森田 博史
東京薬科大学
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長島 伸治
Department of Pharmacognosy, School of Pharmacy, Tokyo University
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Nagashima S
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co.ltd.
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糸川 秀治
東京薬科大学
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