Solution Forms of an Antitumor Cyclic Hexapeptide, RA-VII in Dimethyl Sulfoxide-d_6 from Nuclear Magnetic Resonance Studies
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概要
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Using high-resolution proton nuclear magnetic resonance (^1H-NMR) and carbon-13 nuclear magnetic resonance (^<13>C-NMR) experiments, we have assigned three discernible configurational isomers observed in dimethyl sulfoxide-d_6 (DNSO-d_6) for an antitumor cyclic hexapeptide, RA-VII isolated from Rubia cordifolia. The largest isomer, amounting to 64%, has been assigned as conformer A with only a cis configuration between Tyr-5 and Tyr-6. The second configurational isomer, accounting for 32%, has adopted cis configurations between both Tyr-5 and Tyr-6 and between Ala-2 and Tyr-3. The third isomer, amounting to 4%, was determined to have cis configurations for all of the three N-methyl amide bonds.
- 公益社団法人日本薬学会の論文
- 1992-04-25
著者
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森田 博史
Department of Pharmacognosy, Tokyo College of Pharmacy
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竹谷 孝一
Department of Pharmacognosy, Tokyo College of Pharmacy
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糸川 秀治
Department of Pharmacognosy, Tokyo College of Pharmacy
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森田 博史
Department Of Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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竹谷 孝一
東京都立衛生研究所
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糸川 秀治
東京薬科大学 薬学部
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森田 博史
東京薬科大学
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