The Formation of Cyclic Peroxide from Guaia-6,9-diene as a Model for Hanalpinol Biosynthesis

元データ 1988-08-25 社団法人日本薬学会

概要

Autooxidation and photosensitized oxidation converted guaia-6,9-diene into hanalpinol, both compounds are contained in the rhizomes of Alpinia japonica. This process may be considered to be a biomimetic conversion. Guaia-6,9-diene may be regarded as an immediate precursor of hanalpinol, and a biogenetic pathway has been proposed. The results of molecular orbital calculation (modified neglect of differential overlap (MNDO) method) supported this proposal and provided a basis for conformational analysis.

著者

飯高 洋一 Faculty of Pharmaceutical Sciences, The University of Tokyo
森田 博史 Department of Pharmacognosy, Tokyo College of Pharmacy
糸川 秀治 Department of Pharmacognosy, Tokyo College of Pharmacy
森田 博史 Department Of Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
糸川 秀治 東京薬科大学 薬学部
富岡 伸夫 Faculty Of Pharmaceutical Sciences The University Of Tokyo
飯高 洋一 西東京大・理工
飯高 洋一 Faculty Of Pharmaceutical Sciences The University Of Tokyo

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