Stereochemistry of Macrolides. II. Crystal Structure of p-Bromobenzoylpikromycin

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概要

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• In order to elucidate the stereochemistry of 14-membered macrolactone, an X-ray crystal structural analysis of p-bromobenzoylpikromycin (C_<35>H_<50>O_9NBr・H_2O) was carried out. The crystals are monoclinic with space group P2_1 and unit cell dimensions of a=19.027 (9) Å, b=14.876 (5) Å, c=7.148 (3) Å, β=108.97 (8)°, Z=2. The crystal structure was solved by the heavy-atom method and refined by the block-diagonal least-squares method including anisotropic thermal parameters to a final R value of 0.118. The absolute configuration of pikromycin was determined on the D-desosamine moiety to be 2R, 4R, 5S, 6S, 8R, 12S, 13R, and 10E. A new "diamond lattice"conformation model D for p-bromobenzoylpikromycin is proposed based on the result of X-ray analysis.

• 公益社団法人日本薬学会の論文
• 1977-09-25

著者

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 小倉 治夫

  School of Pharmaceutical Sciences, Kitasato University

• 小倉 治夫

  School Of Pharmaceutical Sciences Kitasato University

• 飯高 洋一

  School Of Medicine Teikyo University

• 飯高 洋一

  西東京科学大学理工学部

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

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