C-Glycosyl Nucleosides. VI. Synthesis and Crystal Structure of Dithiane Glycoside Analog

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概要

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• In order to determine the absolute configuration of product from a reaction of sugar lactone and lithiated heterocycles, and X-ray crystal structural analysis of 1-(1,3-dithian-2-yl)-2,3 : 5,6-di-O-isopropylidene-β-L-gulofuranose was carried out. This compound was prepared from 2,3 : 5,6-di-O-isopropylidene-L-gulono-1,4-lactone and lithiated 1,3-dithiane. The crystals are monoclinic with space group P2_1 and unit cell dimensions of a=18.566 (7) Å, b=9.544 (2) Å, c=6.462 (1) Å, β=91.68 (3)°, z=2. The X-ray analysis was carried out with the heavy-atom method and refined by the block-diagonal least-squares method including anisotropic thermal parameters, and the final R value was 0.071. In conclusion, the absolute configuration of the anomeric position was determined to be R chirality.

• 社団法人日本薬学会の論文
• 1978-09-25

著者

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 高橋 洋

  School Of Pharmaceutical Sciences Kitasato University

• 飯高 洋一

  School Of Medicine Teikyo University

• 飯高 洋一

  西東京科学大学理工学部

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

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