The Molecular and Crystal Structures of Two Derivatives of a Sesterterpene, Ophiobolin D

元データ 1980-04-25 社団法人日本薬学会


The structures of two derivatives of a sesterterpene, ophiobolin D, were determined by X-ray crystallographic analyses. The final R-factors were 0.09 for both compounds. On the basis of their stereo-structures, it is suggested that the compounds are formed by different types of transannular reaction in an eight-membered ring, i. e., a migration of a double bond and a cyclization to yield a novel ring system composed of four fused five-membered rings.


飯高 洋一 Faculty of Pharmaceutical Sciences, The University of Tokyo
野副 重男 Pharmaceutical Institute, Tohoku University
板井 昭子 東大・薬
板井 昭子 Faculty of Pharmaceutical Science, University of Tokyo
野副 重男 Institute Of Applied Microbiology The University Of Tokyo:(present Address)pharmaceutical Institute
野副 重男 Pharmaceutical Institute Tohoku University
板井 昭子 東大 薬
飯高 洋一 Faculty Of Pharmaceutical Sciences The University Of Tokyo