Studies on Tetrahydroisoquinolines. XXIII. Reactions of (±)-7-Acetoxy-7-methoxy-1-(3,4-dimethoxy-or 3,4-methylenedioxybenzyl)-2-methyl-6-oxo-Δ^<4a, 5,8,8a>-hexahydroisoquinoline (o-Quinol Acetate)

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概要

• 論文の詳細を見る

• (±)-4-Acetoxy-1-benzyl-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolines (3) (R=Me) were proved to be formed by thermal isomerization of o-quinol acetates (2). Reaction of 2 with organic acids gave the (±)-1,4-trans-and cis-4-acyloxy-1-benzyl derivatives [3 (R=Me, Et, n-C_5H_<11>, and tert-Bu)]. With hydrohalic acids, 2 afforded (±)-1-benzyl-5-halogeno-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolines [6 (X=Cl, Br)]. Stereochemical aspects of the reactions are discussed.

• 公益社団法人日本薬学会の論文
• 1984-12-25

著者

• 星野 修

  東京理科大学薬学部

• 飯高 洋一

  Nishi-tokyo Science University

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 星野 修

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 梅澤 文輔

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 飯高 洋一

  School Of Medicine Teikyo University

• 飯高 洋一

  西東京大・理工

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 飯高 洋一

  西東京科学大学理工学部

• 梅澤 文輔

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 大谷 実

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 大谷 実

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 星野 修

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

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