A Cyclization of β-Arylethylisocyanates to 3,4-Dihydroisocarbostyrils
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概要
- 論文の詳細を見る
A β-arylethylisocyanate derived from β-(3,4-methylenedioxyphenyl) (3a)-, β-(3,4-dimethoxyphenyl) (3b)-, β-(3,4,5-trimethoxyphenyl) (3c)- or β-(3-methoxyphenyl) (3d)-propionic acid was treated with anhydrous phosphoric acid at room temperature to give, in moderate yield, 6,7-methylenedioxy (4a)-, 6,7-dimethoxy (4b)-, 6,7,8-trimethoxy (4c)-, or 6-methoxy (4d)- and 8-methoxy (4d')-3,4-dihydroisocarbostyrils. In the case of β-(4-benzyloxy-3-methoxyphenyl) (3e)- or β-(3-benzyloxy-4-methoxyphenyl) (3f)-propionic acid, however, only 8-benzyl-7-hydroxy-6-methoxy (4e)- or 5-benzyl-6-hydroxy-7-methoxy (4f)-3,4-dihydroisocarbostyril, respectively, was obtained in low yield.
- 公益社団法人日本薬学会の論文
- 1980-03-25
著者
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星野 修
東京理科大学薬学部
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星野 修
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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梅沢 文輔
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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沢木 正平
東京理科大薬
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梅澤 文輔
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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梅沢 文輔
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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沢木 正平
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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森 和彦
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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星野 修
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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