Studies on Tetrahydroisoquinolines. XII. An Alternative Synthesis of (±)-Bracteoline, (±)-Isoboldine, (±)-N-Methyllaurotetanine, and Their Related Aporphines
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概要
- 論文の詳細を見る
By the treatment of the p-quinol acetate (Xa) and (Xb) with trifluoroacetic acid, (±)-10-benzyloxy-1-hydroxy-2,9-dimethoxyaporphine (XIa) and (±)-9-benzyloxy-1-hydroxy-2,10-dimethoxyaporphine (XIb) were given in good yield, respectively. Furthermore, XIa and XIb were converted to (±)-bracteoline (XIIa) and (±)-isoboldine (XIIb) by catalytic debenzylation, or to (±)-10-hydroxy-1,2,9-trimethoxyaporphine (XIVa) and (±)-N-methyllaurotetanine (XIVb) by methylation and successive debenzylation, respectively.
- 社団法人日本薬学会の論文
- 1976-08-25
著者
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星野 修
東京理科大学薬学部
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原 博
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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原 博
東京理科大学薬学部
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星野 修
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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梅澤 文輔
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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梅澤 文輔
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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星野 修
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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