Studies on Tetrahydroisoquinolines. III. Synthesis of 4-Alkoxy- or Alkyl (phenyl)-mercapto-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolines

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概要

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• Treatment of 4,7-diacetate (I) with alcohols or alkyl (phenyl) mercaptans in the presence of base gave the corresponding 4-alkoxy or alkyl (phenyl) mercapto derivatives (VIak) in moderate yields. In the case of alcohols, the steric effect of alkyl chains was found to be governing as expected. Nuclear magnetic resonance spectra of the products were measured and magnetic nonequivalence of isopropoxyl methyl protons due to hindered rotation was observed in the case of 4-isopropoxy compound (VIf).

• 公益社団法人日本薬学会の論文
• 1971-10-25

著者

• 梅澤 文輔

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 星野 修

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 山梨 安弘

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

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