Kinetic Resolution of (±)-4-Acyloxy-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisopuinolines by Use of Immobilized Lipases in Organic Solvents

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概要

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• Kinetic resolution of (±)-4-acyloxytetrahydroisoquinolines (5-7) by use of lipases immobilized on Celite in isooctane or cyclohexane saturated with water was carried out to give 4S-(+)-tetrahydroisoquinolin-4-ol (8) in a high optical purity. The absolute configuration of (+)-8 was determined by comparison of the spectral data and specific rotation with those of authentic 4R-(-)-tetrahydroisoquinolin-4-ol (8) derived from R-(-)-epinephrine (9).

• 公益社団法人日本薬学会の論文
• 1990-12-25

著者

• 星野 修

  東京理科大学薬学部

• 秋田 弘幸

  School of Pharmaceutical Sciences, Toho University

• 秋田 弘幸

  Riken Institute (The Institute of Physical and Chemical Research)

• 大石 武

  Riken Institute (The Institute of Physical and Chemical Research)

• 大石 武

  Faculty Of Engineering Yokohama National University:(present Address)meiji College Of Pharmacy

• 星野 修

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 梅澤 文輔

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 大石 武

  理研:(現)明治薬科大学

• 伊藤 勝彦

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 秋田 弘幸

  School Of Pharmaceutical Science Toho University

• 秋田 弘幸

  理化学研究所

• 梅澤 文輔

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 星野 修

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

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