SYNTHESIS OF USEFUL CHIRAL SYNTHONS (2R, 3R)-2-METHYLMALATE AND ITS CONGENERS VIA MICROBIAL ASYMMETRIC REDUCTION
スポンサーリンク
概要
- 論文の詳細を見る
Asymmetric reduction of the commercially available diethyl 2-methyl-3-oxo-succinate 4___〜 with Candida albicans gave a mixture of (3R)-methylmalates 5___〜a and 5___〜b.These were subjected to simple chemical processes and subsequent column chromatographic separation to provide the optically pure, useful chiral synthon 6___〜 or 7___〜a in good yield.
- 社団法人日本薬学会の論文
- 1986-06-25
著者
-
秋田 弘幸
Riken Institute (The Institute of Physical and Chemical Research)
-
松倉 弘子
Riken Institute (The Institute of Physical and Chemical Research)
-
大石 武
Riken Institute (The Institute of Physical and Chemical Research)
-
松倉 弘子
Riken Institute(the Institute Of Physical And Chemical Research)
-
秋田 弘幸
School Of Pharmaceutical Science Toho University
-
秋田 弘幸
理化学研究所
関連論文
- Reaction of Methyl 4,5-Epoxy-(2E)-pentenoate with Arenes. II. Application to the Synthesis of (±)-Curcudiol, (±)-Curcuphenol, (±)-Curcuhydroquinone, and (±)-Curcuquinone
- Reaction of Methyl 4,5-Epoxy-(2E)-pentenoate with Arenes. I. A Facile Synthesis of 4-Aryl-5-hydroxy-(2E)-pentenoate Derivatives
- The Regioselective Dehydration of Unsymmetrical Secondary Alcohols under Mitsunobu's Reaction Conditions
- ENZYMATIC HYDROLYSIS IN ORGANIC SOLVENTS FOR KINETIC RESOLUTION OF WATER-INSOLUBLE α-ACYLOXY ESTERS WITH IMMOBILIZED LIPASES
- 29 20員環マクロライド抗生物質、ベンツリシジンの合成研究(口頭発表の部)
- Total Synthesis of (±)-, (-)-, and (+)-Oudemansin X
- Formal Syntheses of N-Trifluoroacetyl-L-acosamine and N-Trifluoroacetyl-L-daunosamine from an Achiral Precursor, Methyl Sorbate
- Synthesis of Ozonolysis Products of Myxothiazol
- カイコへのアビエチン酸誘導体の経口投与による3眠蚕の出現
- 7 ベンゾニリデン型ジテルペンの転位反応
- Syntheses of optically Active (+)-Fragrolide and (+)-Bemadienolide from Dehydroabietic Acid
- 72 ジテルペン系フェノール誘導体のオゾン酸化 : 光学活性ドリマン型セスキテルペン類及びフラノセスキテルペンの合成
- A Facile Chemoenzymatic Route to Optically Active 4,5-Disubstituted-2E-hexenoate Derivatives. I
- Enantioselective Acetylation of an α-Hydroxy Ester by Using Ether-Linked Lipid-Lipase Aggregates in Organic Solvents
- A Formal Total Synthesis of (-)-Oudemansin B
- A Lipid-Lipase Aggregate with Ether Linkage as a New Type of Immobilized Enzyme for Enantioselective Hydrolysis in Organic Solvents
- A FACILE CHEMOENZYMATIC ROUTE TO ENANTIOMERICALLY PURE 4,5-DISUBSTITUTED-2-HEXENOATE DERIVATIVES
- A LIPID LIPASE AGGREGATE AS A NEW TYPE OF IMMOBILIZED ENZYME
- Asymmetric Reduction of α-Methyl β-Keto Esters by Microbial Cells Immobilized with Prepolymer(Organic,Chemical)
- 38 生体触媒を用いるキラルシントンの合成とその天然物合成への応用
- SYNTHESIS OF USEFUL CHIRAL SYNTHONS (2R, 3R)-2-METHYLMALATE AND ITS CONGENERS VIA MICROBIAL ASYMMETRIC REDUCTION
- Reduction of Nitroolefin Using Microorganisms
- 5 天然視物質の発色団を保有した非退色性ロドプシン
- Microbiologically Modified Chiral Synthon. III. 4,9-Dimethyl-3,5-dioxo-Δ^-octalin for Formal Total Syntheses of Certain Sesquiterpenoids
- MICROBIOLOGICAL ASYMMETRIC INDUCTION OF 4,9-DIMETHYL-3,5-DIOXO-Δ^-OCTALIN
- Microbiologically Modified Chiral Synthon. II. : 4,9-Dimethyl-3,7-dioxo-Δ^-octalin for Formal Total Syntheses of Certain C(8) Oxygenated Sesquiterpenoids
- Microbiologically Modified Chiral Synthon. I. 3,8-Dioxo-4-methoxycarbonyl-9-methyl-Δ^-octalin for Formal Total Syntheses of Certain Sesquiterpenoids and Diterpenoids
- MICROBIOLOGICALLY MODIFIED 4,9-DIMETHYL-Δ^-OCTAL-3,7-DIONES AS THE CHIRAL SYNTHON FOR FORMAL TOTAL SYNTHESES OF C(8) OXYGENATED SESQUITERPENOIDS(Communications to the Editor)
- MICROBIOLOGICAL ASYMMETRIC REDUCTION OF 4-CARBOMETHOXY-3,8-DIOXO-9-METHYL-Δ^-OCTALIN
- The Use of Microorganisms in Oraganic Synthesis. V. Microbiological Asymmetric Reduction of Methyl 2-Methyl-3-(2-thienyl)-3-oxopropionate
- The Use of Microorganisms in Organic Synthesis. IV. Microbiological Asymmetric Reduction of Methyl 3-Phenyl 2-Oxobutyrate
- The Use of Microorganisms in Organic Synthesis. III. Microbiological Asymmetric Reduction of Methyl 3-(2-Furyl)-2-methyl-3-oxopropionate
- THE USE OF A VERSATILE BUILDING BLOCK HAVING TWO CHIRAL CENTERS A TOTAL SYNTHESIS OF (-)-OUDEMANSIN
- The Use of Microorganisms in Organic Synthesis. II. Microbiological Asymmetric Reduction of 2-Methyl-3-oxosuccinates
- The Use of Microorganisms in Organic Synthesis. I. Microbiological Asymmetric Reduction of 2-Methyl-3-oxobutyrates
- Synthesis of (+)- and (-)-cis-α-Irones
- Studies on Taxane Synthesis III.Stereocontrolled Synthesis of a Twelve-Membered Lactam Sulfide as a Precursor of 4,8,11,11-Tetramethyl-3-oxobicyclo[5.3.1]undec-8-ene
- Studies on Taxane Synthesis. II. : Synthese of 3,8,11,11-Tetramethyl-4-oxo- and 4,8,11,11-Tetramethyl-3-oxo-bicyclo[5.3.1]undec-8-enes Corresponding to the A- and B-Rings of Taxane Diterpenes
- Studies on Taxane Synthesis. I. : Synthesis of 3,8,11,11-Tetramethyl-4-oxobicyclo[5.3.1]undecane as a Model for Taxane Synthesis
- Revised Stereostructure for (+)-Roemecarine and Synthesis of (±)-, (+)-, and (-)-Roemercarine and (±)-Epiroemecarine
- Kinetic Resolution of (±)-4-Acyloxy-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisopuinolines by Use of Immobilized Lipases in Organic Solvents
- Preparation of Chiral, Highly Functionalized Cyclopentenones
- Enzymatic Procedure for the Synthesis of 11-Deoxyprostaglandins(Organic,Chemical)
- Enzymatic Synthesis of 2,3-O-Isopropylidene-sn-glycerol, a Chiral Building Block for Platelet-Activating Factor
- USING MICROBIAL REDUCTION TO SYNTHESIZE CARBACYCLIN
- 12 微生物還元を利用する光学活性有用化合物の合成およびその天然物合成への応用
- Asymmetric Reduction of 2-Aminobenzophenone Using Yeast, Rhodosporidium toruloides
- Diterpenoids. XLV. Ozonolysis of Phenolic Dehydroabietic Acid Derivatives
- DETERMINATION OF THE STEREOSTRUCTURE OF THE δ-LACTONES OF 5,7-DIHYDROXY-2,3-UNSATURATED ACIDS BY ^1H NMR SPECTROSCOPY(Communications to the Editor)
- Formal Total Synthesis of (-(-Indolmycin
- A FORMAL SYNTHESIS OF l-α-SANTONIN FROM CHIRAL α, β-EPOXYEUDESMANOLIDE VIA ENZYME-CATALYZED HYDROLYSIS
- A Facile Chemoenzymatic Route to Optically Active 4,5-Disubstituted-2E-hexenoate Derivatives. II
- 微生物を利用する不斉還元
- A Total Synthesis of (±)-Warburganal
- 28 摂食阻止物質(±)-Warburgana/およびその関連化合物の全合成
- Diterpenoids. XLI. Rearrangement of Deisopropyl Phenacylidene Type Diterpene by Means of Aluminum Chloride
- Diterpenoids. XXXVII. Rearrangement of Methyl 13-Isopropyl-7-oxo-podocarpa-5,8,11,13-tetraen-15-oate by Means of Aluminum Chloride
- Diterpenoids. XXXI. Reaction of Methyl Dehydroabietate Derivatives with Aluminum Chloride under Effect of Electron-withdrawing Group. Synthesis of Methyl Deisopropyldehydroabietate Series
- Diterpenoids. XXX. Reaction of Methyl Dehydroabietate Derivatives with Aluminum Chloride under Effect of Electron-donating Group
- Diterpenoids. XXIX. Nitration of Methyl Dehydroabietate Derivatives
- Diterpenoids. XXVIII. Nitration of Methyl 7-Oxo-dehydroabietate Derivatives
- Novel Nitration Reaction of Methyl 7-Oxodehydroabietate
- Structural Characteristics of Lipid-Lipase Aggregates for Enantioselective Hydrolysis in Organic Solvents
- リパーゼを用いる光学活性ヒドロキシエステルの創製とその生理活性化合物合成への応用 : ベンツリシジンA, Bアグリコンの全合成
- 微生物, 酵素機能を用いる有機合成.ベンツリシジンA, Bアグリコンの全合成
- β-HYDROXY-δ-LACTONES AS CHIRAL BUILDING BLOCKS INVOLVING 1,3-DIHYDROXYL FUNCTIONS. 1. : NEW STRATEGIES FOR STREOSELECTIVE CONSTRUCTION OF 2-METHYL-3,5-DIHYDROXY ESTERS
- Highly syn-Selective Reduction of α-Phenylthio-β-methoxy Ketones with Super-hydride
- アビエチン酸の化学的研究 : 生理活性天然物の合成をめざして
- 微生物酵素機能の有機合成への応用
- SYNTHESIS BY MICROBIAL REDUCTION OF (S)-13-HYDROXY-9Z, 11E-OCTADECADIENOIC ACID, A DEFENSIVE SUBSTANCE IN RICE
- 運営に対する研究者の積極的な協力参加を(大型機器の運用について)
- A SHORT PATH SYNTHESIS OF RETINALS. SYNTHESIS OF ^C-OR ^2H-LABELED RETINALS
- 微生物を利用した二個のキラル中心を含む光学活性シントンの合成
- Large Scale Syntheses of (±)-Isodrimenin and (±)-Confertifolin
- Ozonolysis of Phenolic Dehydroabietane Derivatives. : Syntheses of optically Active (+)-Confertifolin, (+)-Valdiviolide, (+)-Winterin, (+)-Isodrimenin, and (+)-Pallescensin A
- Aromatic Substitution in Dehydroabietane Derivatives. : Syntheses of the Phenolic Dehydroabietane Series