微生物を利用した二個のキラル中心を含む光学活性シントンの合成
スポンサーリンク
概要
- 論文の詳細を見る
Asymmetric reduction of α-methyl β-keto ester and β-methyl α-keto ester by means of yeasts was carried out. Both keto esters were found to be reduced by a variety of yeasts to give optically active hydroxy esters having two chiral centers. The absolute configuration and the optical purity of the reduction products were primarily determined by measuring the 400 MHz NMR spectra of the (+) -MTPA esters of the alcohols produced.<BR>The successful use of the chiral synthons prepared by the present method in high optical purity to the synthesis of (-) -oudemansin is described.
- 社団法人 有機合成化学協会の論文
著者
関連論文
- ENZYMATIC HYDROLYSIS IN ORGANIC SOLVENTS FOR KINETIC RESOLUTION OF WATER-INSOLUBLE α-ACYLOXY ESTERS WITH IMMOBILIZED LIPASES
- カイコへのアビエチン酸誘導体の経口投与による3眠蚕の出現
- Syntheses of optically Active (+)-Fragrolide and (+)-Bemadienolide from Dehydroabietic Acid
- 72 ジテルペン系フェノール誘導体のオゾン酸化 : 光学活性ドリマン型セスキテルペン類及びフラノセスキテルペンの合成
- A Facile Chemoenzymatic Route to Optically Active 4,5-Disubstituted-2E-hexenoate Derivatives. I
- Enantioselective Acetylation of an α-Hydroxy Ester by Using Ether-Linked Lipid-Lipase Aggregates in Organic Solvents
- A Formal Total Synthesis of (-)-Oudemansin B
- A Lipid-Lipase Aggregate with Ether Linkage as a New Type of Immobilized Enzyme for Enantioselective Hydrolysis in Organic Solvents
- A FACILE CHEMOENZYMATIC ROUTE TO ENANTIOMERICALLY PURE 4,5-DISUBSTITUTED-2-HEXENOATE DERIVATIVES
- A LIPID LIPASE AGGREGATE AS A NEW TYPE OF IMMOBILIZED ENZYME
- Asymmetric Reduction of α-Methyl β-Keto Esters by Microbial Cells Immobilized with Prepolymer(Organic,Chemical)
- 38 生体触媒を用いるキラルシントンの合成とその天然物合成への応用
- SYNTHESIS OF USEFUL CHIRAL SYNTHONS (2R, 3R)-2-METHYLMALATE AND ITS CONGENERS VIA MICROBIAL ASYMMETRIC REDUCTION
- Reduction of Nitroolefin Using Microorganisms
- 5 天然視物質の発色団を保有した非退色性ロドプシン
- 米国産NTU頁岩油成分の研究(第10報)コロラド産頁岩油の軽油留分より(+)-Drim-8-eneの検出
- Microbiologically Modified Chiral Synthon. III. 4,9-Dimethyl-3,5-dioxo-Δ^-octalin for Formal Total Syntheses of Certain Sesquiterpenoids
- MICROBIOLOGICAL ASYMMETRIC INDUCTION OF 4,9-DIMETHYL-3,5-DIOXO-Δ^-OCTALIN
- Microbiologically Modified Chiral Synthon. II. : 4,9-Dimethyl-3,7-dioxo-Δ^-octalin for Formal Total Syntheses of Certain C(8) Oxygenated Sesquiterpenoids
- Microbiologically Modified Chiral Synthon. I. 3,8-Dioxo-4-methoxycarbonyl-9-methyl-Δ^-octalin for Formal Total Syntheses of Certain Sesquiterpenoids and Diterpenoids
- MICROBIOLOGICALLY MODIFIED 4,9-DIMETHYL-Δ^-OCTAL-3,7-DIONES AS THE CHIRAL SYNTHON FOR FORMAL TOTAL SYNTHESES OF C(8) OXYGENATED SESQUITERPENOIDS(Communications to the Editor)
- MICROBIOLOGICAL ASYMMETRIC REDUCTION OF 4-CARBOMETHOXY-3,8-DIOXO-9-METHYL-Δ^-OCTALIN
- The Use of Microorganisms in Oraganic Synthesis. V. Microbiological Asymmetric Reduction of Methyl 2-Methyl-3-(2-thienyl)-3-oxopropionate
- The Use of Microorganisms in Organic Synthesis. IV. Microbiological Asymmetric Reduction of Methyl 3-Phenyl 2-Oxobutyrate
- The Use of Microorganisms in Organic Synthesis. III. Microbiological Asymmetric Reduction of Methyl 3-(2-Furyl)-2-methyl-3-oxopropionate
- THE USE OF A VERSATILE BUILDING BLOCK HAVING TWO CHIRAL CENTERS A TOTAL SYNTHESIS OF (-)-OUDEMANSIN
- The Use of Microorganisms in Organic Synthesis. II. Microbiological Asymmetric Reduction of 2-Methyl-3-oxosuccinates
- The Use of Microorganisms in Organic Synthesis. I. Microbiological Asymmetric Reduction of 2-Methyl-3-oxobutyrates
- 「基礎科学特別研究員制度」設立に関連して想う
- 高選択的新規反応の開発と有用天然物合成への応用
- エリスロマイシンA合成研究をめぐって
- オリゴヌクレオチド合成技術の進歩とヒト成長ホルモン遺伝子の合成
- Revised Stereostructure for (+)-Roemecarine and Synthesis of (±)-, (+)-, and (-)-Roemercarine and (±)-Epiroemecarine
- Kinetic Resolution of (±)-4-Acyloxy-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisopuinolines by Use of Immobilized Lipases in Organic Solvents
- Preparation of Chiral, Highly Functionalized Cyclopentenones
- Enzymatic Procedure for the Synthesis of 11-Deoxyprostaglandins(Organic,Chemical)
- Enzymatic Synthesis of 2,3-O-Isopropylidene-sn-glycerol, a Chiral Building Block for Platelet-Activating Factor
- USING MICROBIAL REDUCTION TO SYNTHESIZE CARBACYCLIN
- 12 微生物還元を利用する光学活性有用化合物の合成およびその天然物合成への応用
- Asymmetric Reduction of 2-Aminobenzophenone Using Yeast, Rhodosporidium toruloides
- Formal Total Synthesis of (-(-Indolmycin
- A FORMAL SYNTHESIS OF l-α-SANTONIN FROM CHIRAL α, β-EPOXYEUDESMANOLIDE VIA ENZYME-CATALYZED HYDROLYSIS
- A Facile Chemoenzymatic Route to Optically Active 4,5-Disubstituted-2E-hexenoate Derivatives. II
- Structural Characteristics of Lipid-Lipase Aggregates for Enantioselective Hydrolysis in Organic Solvents
- リパーゼを用いる光学活性ヒドロキシエステルの創製とその生理活性化合物合成への応用 : ベンツリシジンA, Bアグリコンの全合成
- 微生物, 酵素機能を用いる有機合成.ベンツリシジンA, Bアグリコンの全合成
- アビエチン酸の化学的研究 : 生理活性天然物の合成をめざして
- 非環状化合物におけるケトンの立体選択的還元と天然物合成への応用
- 微生物酵素機能の有機合成への応用
- SYNTHESIS BY MICROBIAL REDUCTION OF (S)-13-HYDROXY-9Z, 11E-OCTADECADIENOIC ACID, A DEFENSIVE SUBSTANCE IN RICE
- 運営に対する研究者の積極的な協力参加を(大型機器の運用について)
- A SHORT PATH SYNTHESIS OF RETINALS. SYNTHESIS OF ^C-OR ^2H-LABELED RETINALS
- 微生物を利用した二個のキラル中心を含む光学活性シントンの合成
- カリウムアニオン・トルエンラジカルアニオン
- Large Scale Syntheses of (±)-Isodrimenin and (±)-Confertifolin
- Ozonolysis of Phenolic Dehydroabietane Derivatives. : Syntheses of optically Active (+)-Confertifolin, (+)-Valdiviolide, (+)-Winterin, (+)-Isodrimenin, and (+)-Pallescensin A
- Aromatic Substitution in Dehydroabietane Derivatives. : Syntheses of the Phenolic Dehydroabietane Series
- 1, 3-syn-およびanti-あポリオール系の立体選択的合成研究と天然物合成への応用
- 一般合成における保護基--水酸基の保護 (保護基)