MICROBIOLOGICALLY MODIFIED 4,9-DIMETHYL-Δ^<4(10)>-OCTAL-3,7-DIONES AS THE CHIRAL SYNTHON FOR FORMAL TOTAL SYNTHESES OF C(8) OXYGENATED SESQUITERPENOIDS(Communications to the Editor)

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概要

• 論文の詳細を見る

• 4, (9S)- (2a) and 4, (9R)-dimethyl-(7S)-hydroxy-Δ^<4(10)>-octal-3-one (2b) were prepared in high optical purity (> 99% ee) and in moderate yield by asymmetric reduction of the corresponding racemic diketone (lab) using yeasts. These compounds were used for the formal total syntbesis of C(8) oxygenated sesquiterpenoids such as (-)-artemisin, (-)-yomogin, (-)-3-oxodiplophyllin, β-elemenone, (+)-isotelekin and (+)-cuauhtemone.

• 公益社団法人日本薬学会の論文
• 1987-01-25

著者

• 大倉 多美子

  Pharmaceutical Institute School Of Medicine Keio University

• 飯高 洋一

  Nishi-tokyo Science University

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 稲山 誠一

  Pharmaceutical Institute, School of Medicine, Keio University

• 飯高 洋一

  School Of Medicine Teikyo University

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 飯高 洋一

  西東京科学大学理工学部

• 秋田 弘幸

  School Of Pharmaceutical Science Toho University

• 秋田 弘幸

  理化学研究所

• 清水 信子

  Pharmaceutical Institute, School of Medicine, Keio University

• 秋田 弘幸

  Institute of Physical and Chemical Research

• 大石 武

  Institute of Physical and Chemical Research

• 稲山 誠一

  Institute Of Oriental Medical Sciences

• 稲山 誠一

  Pharmaceutical Institute School Of Medicine Keio University

• 稲山 誠一

  慶應義塾大学医学部薬化学研究所

• 清水 信子

  Pharmaceutical Institute School Of Medicine Keio University

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

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