The Complete Structure of Spathulin, a Crystallographic Study of Diacetylspathulin

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概要

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• The molecular structure of spathulin (1a), a highly oxygenated pseudoguaianolide isolated from Gaillardia grandiflora has been established by a three dimensional X-ray crystallographic analysis of diacetylspathulin (1b). The space group of the crystal of 1b is P2_12_12_1 and the dimensions of the cell with z=4 are a=9.6976 (3), b=26.968 (2), c=8.9288 (3) Å. The structure of the crystal was refined to R=0.05. The conformation of spathulin (1a) was estimated to be similar to that of pulchellin (2a), namely bis-deacetoxyspathulin except some differences particularly at C (6) and C (9), when the conformation of the pseudoguaianolide skeleton in 1b is compared with that in 11,13-dibromopulchellin (2b).

• 公益社団法人日本薬学会の論文
• 1977-08-25

著者

• 大倉 多美子

  Pharmaceutical Institute School Of Medicine Keio University

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 飯高 洋一

  西東京科学大学理工学部

• 稲山 誠一

  Institute Of Oriental Medical Sciences

• 稲山 誠一

  慶應義塾大学医学部薬化学研究所

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

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