The Crystal Structure of the Bromoacetylated Dimer-A synthesized by the Reaction of Acridine with Hydroxylamine-O-sulfonic Acid

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概要

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• The structure of the bromoacetylated dimer-A (BADA) benzene solvate ; C_<30>H_<26>O_2N_6Br_2・C_6H_6 has been determined by X-ray diffraction method in order to elucidate the dimer-A structure ; (C_<13>H_<12>N_3)_2 obtained by the reaction of acridine with hydroxylamine-O-sulfonic acid (NH_2OSO_3H, HAS). The crystals ; BADA・C_6H_6 are triclinic with space group P_1-and the unit-cell dimensions are a=9.167,b=10.618,c=10.379Å, α=99.60,β=119.61,γ=95.21°. One formula unit is contained in the cell. The crystal structure was solved by the heavy-atom method and refined by the block-matrix least-squares method including anisotropic thermal parameters. The final R value for 1106 non-zero observed structure factors was 0.07. BADA was found to be a benzalazine derivative, 2,2'-(2-bromoacetylaminoanilino)-benzalazine. On the basis of the result obtained by the present determination and the comparison of ultraviolet and nuclear magnetic resonance spectra, the structure of dimer-A has been established.

• 公益社団法人日本薬学会の論文
• 1974-09-25

著者

• 広部 雅昭

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 岡本 敏彦

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 岡本 敏彦

  東大・薬

• 岡本 敏彦

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 岡本 敏彦

  千葉大学薬学部

• 尾沢 鉄男

  Faculty Of Parmaceutical Sciences University Of Tokyo

• 広部 雅昭

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 広部 雅昭

  東京大学薬学部:文部省

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

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