A Novel Metabolite of 3,4-Methylenedioxyamphetamine (MDA) : Formation of 3-Methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline and Its Pharmacological Effect
スポンサーリンク
概要
- 論文の詳細を見る
In 3,4-methylenedioxyamphetamine (MDA)-treated rat brain and urine, 3-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline (3Me6,7MDTIQ) was detected as a new metabolite. The content of 3Me6,7MDTIQ in (R)-MDA-treated rat was significantly higher than that in (S)-MDA-treated brain and urine. This result suggests that this metabolism of MDA contains stereoselective pathways.The pharmacological effects of 3Me6,7MDTIQ on behavior differed from those of MDA. The ambulation score of 3Me6,7MDTIQ was significantly decreased compared to the control, and the rearing score of 3Me6,7MDTIQ was moderately decreased compared to the control in an open-field test.
- 公益社団法人日本薬学会の論文
- 1993-06-15
著者
-
太田 成男
日本医科大学老人病研究所
-
吉田 幸弘
Faculty Of Pharmaceutical Sciences University Of Tokyo
-
広部 雅昭
Faculty of Pharmaceutical Sciences, University of Tokyo
-
太田 茂
Faculty of Pharmaceutical Sciences, University of Tokyo
-
中川 秀彦
Faculty of Pharmaceutical Sciences, University of Tokyo
-
牧野 由紀子
Faculty of Pharmaceutical Sciences, University of Tokyo
-
広部 雅昭
Faculty Of Pharmaceutical Sciences University Of Tokyo
-
広部 雅昭
東京大学薬学部:文部省
-
牧野 由紀子
Faculty Of Pharmaceutical Sciences University Of Tokyo
-
中川 秀彦
Faculty Of Pharmaceutical Sciences University Of Tokyo
関連論文
- DP-126-3 抗癌剤耐性とミトコンドリアDNA体細胞変異の関連における分子生物学的検討(第108回日本外科学会定期学術集会)
- O-1-97 膵臓癌細胞の抗癌剤耐性とミトコンドリアDNA体細胞変異の関連(胆・膵 研究3,一般演題(口演),第63回日本消化器外科学会総会)
- DP-150-5 大腸癌細胞株を用いたCybridの作製と抗癌剤感受性におけるミトコンドリアDNA体細胞変異の関連(第108回日本外科学会定期学術集会)
- DP-150-4 大腸癌における5FU,S-1抗癌剤感受性試験の樹立とミトコンドリアDNAの変異(第108回日本外科学会定期学術集会)
- P-1-634 FOLFOXを指標とした大腸癌治療 : in vitro抗癌剤感受性試験の樹立とミトコンドリアDNA変異(大腸・肛門 他・化療,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)
- 水素ガスと水素水による新しい概念の抗酸化治療法と予防医学
- BACTERIOSTATIC EFFECT OF 4,7-DICYANOBENZOFURAZAN DUE TO INACTIVATION OF 2,3-DIHYDROXYISOVALERATE DEHYDRATASE
- FORMATION OF SUPEROXIDE BY BENZOFURAZANS IN ESCHERICHIA COLI UNDER AEROBIC INCUBATION
- Toxicities of Dicyanobenzofurazans with Formation of Superoxide in Escherichia coli
- Degradation of 1,3-Diaryl-1-nitrosoureas in Aqueous Solutions and in Organic Solvents(Organic,Chemical)