COMPARISON OF THE REACTIVITIES OF [Fe_4S_4(SPh)_4]^<2-> AND [Fe_2S_2(SPh)_4]^<2->

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概要

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• The reactivities of the model complexes, [Fe_4S_4(SPh)_4]^<2-> (1) and [Fe_2S_2(SPh)_4]^<2-> (2), of nonheme iron-sulfur proteins were compared. Complex 1 catalyzed the oxidation of benzenethiol to diphenyl disulfide with the reduction of dioxygen to H_2O. Complex 2 did not catalyze it, but the reaction proceeded after an induction period during which complex 2 was converted to complex 1. In addition, complex 1 catalyzed the reduction of 1,4-dinitrobenzene to N -(4-nitrophenyl)hydroxylamine (21 %) and 4-nitroaniline (16 %) with the oxidation of benzenethiol to diphenyl disulfide, but complex 2 induced mainly the displacement of nitro group to phenylthio group to give 1-nitro-4-(phenylthio)benzene (92 %). It was revealed that the reactivities of complex 1 complex 2 are quite different.

• 公益社団法人日本薬学会の論文
• 1993-01-15

著者

• 長野 哲雄

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 広部 雅昭

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 柳田 一夫

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 広部 雅昭

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 広部 雅昭

  東京大学薬学部:文部省

• 柳田 一夫

  Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Adress)faculty Of Pharmaceutical Sci

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