Synthesis and Analgesic Activity of Morphine-7,8-oxide and Heroin-7,8-oxide

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概要

• 論文の詳細を見る

• Morphine-7,8-oxide (1) was synthesized from 3-methoxymethylmorphinone-7,8-oxide which was obtained by the oxidation of 3-methoxymethylmorphinone with H_2O_2. Heroin-7,8-oxide (2) was also synthesized from 1. The analgesic activity of 7,8-epoxides (1,2 and codeine-7,8-oxide) was determined by the method of pressure stimuli on the rat tail. 2 was the most analgesic among all of them. In comparison with each of their parent compound (morphine, heroin and codeine), the introduction of the 7,8-epoxy moiety into morphine skeleton resulted in some increase in their analgesic activity.

• 社団法人日本薬学会の論文
• 1980-12-25

著者

• 広部 雅昭

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 宮田 直樹

  National Institute Of Hygienic Sciences University Of Tokyo

• 宮田 直樹

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 鳥羽 希代子

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 渡辺 敬三

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 鳥羽 希代子

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 渡辺 敬三

  東京大学薬学部

• 広部 雅昭

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 広部 雅昭

  東京大学薬学部:文部省

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