コルベン内代謝反応--生体機能を化学的に模倣する (自然に学ぶ化学<特集>) -- (生体との対話)

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概要

• 論文の詳細を見る
• 化学同人の論文

著者

• 広部 雅昭

  東京大学薬学部:文部省

関連論文

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• FORMATION OF SUPEROXIDE BY BENZOFURAZANS IN ESCHERICHIA COLI UNDER AEROBIC INCUBATION
• Toxicities of Dicyanobenzofurazans with Formation of Superoxide in Escherichia coli
• Degradation of 1,3-Diaryl-1-nitrosoureas in Aqueous Solutions and in Organic Solvents(Organic,Chemical)
• Studies on the Oxidation of 5H-N-Substituted Dibenz[b, f]azepines. III. : Oxidative Metabolism by Rat Liver Microsomes
• Studies on the Oxidation of N-Substituted-dibenz [b, f] azepines. II. Syntheses and Reactions of 5H-Dibenz [b, f] azepine 10,11-Oxides
• OXIDATION OF TERTIARY AMINES AND SULFIDES BY AN IRON (III) PORPHYRIN-O_2-Na_2S_2O_4 SYSTEM AS A MODEL OF CYTOCHROME P-450
• DEOXYGENATION OF TERTIARY AMINE N-OXIDES AND ARENE OXIDES BY IRON (II) PORPHYRIN AS A MODEL OF CYTOCHROME P-450 DEPENDENT REDUCTION
• Oxidative Dealkylation of Tertiary Amines by Iron (III) Porphyrin-Iodosoxylene System as a Model of Cytochrome P-450
• Studies on the Oxidation of N-Substituted-dibenz [b, f] azepines I. Oxidation with m-Chloroperbenzoic Acid
• Synthesis and Analgesic Activity of Morphine-7,8-oxide and Heroin-7,8-oxide
• Codeine-7,8-oxide (4,5α-Epoxy-7β, 8β-epoxy-3-methoxy-17-methylmorphinan-6α-ol) : Identification as a Metabolite of Codeine
• Stereospecific Synthesis of Codeine 7,8-Oxide and Codeinone 7,8-Oxide
• INTER-INDIVIDUAL DIFFERENCES OF (+)-4-[4-(4-METHYLPHENYL)PHENYLMETHOXY-1-PIPERIDINYL]BUTYRIC ACID ((+)-MPPB) DISPOSITION IN RATS
• N-Aminopyridinium誘導体の反応(第11報) : N-Benzylideneamino Pyridinium塩誘導体とシアニドイオンとの反応 : 5-Aminooxazole誘導体の新合成法
• N-Aminopyridinium誘導体の反応(第8報) : N-Aminopyridinium塩とアルデヒド類との反応
• DOCA-食塩高血圧ラットの内皮由来一酸化窒素(NO)の遊離に及ぼすL-Arginine(L-Arg)長期投与の影響 : ポスター発表 : 第57回日本循環器学会学術集会
• NEW METHOD OF DETECTING NITRIC OXIDE PRODUCTION
• 実験高血圧ラットにおける内皮依存性腎血管拡張反応の低下機序の検討
• 12. 化学構造とCytokinin活性
• 薬学教育モデルカリキュラム作成に当っての考え方 : 薬学教育、薬剤師教育に関する基本姿勢
• Mass Fragmentographyによる尿中Heroinの検出
• 創薬科学を構想する
• Clusters [Fe_4S_4(SR)_4]^ as Novel Catalysts in Organic Reductions
• Synthetic Antimicrobials. II. Synthesis of Pyrazolo [1,5-a] pyridine Derivatives. (1)
• 合成抗菌剤の研究(第1報)ピリジン-4-チオカルボンアミド誘導体の合成
• Steric and Electronic Effects of Methyl Substitutents at the 2- and 6-Positions on N-Benzyl-1.4-dihydronicotinamide(Organic,Chemical)
• 医薬化学部会の設立について
• Novel Rearrangement of Pyrazole N-Imines with Acetic Anhydride
• Syntheses of Novel Antimicrobial Compounds : Pyrazolo [5,1-b] thiazole, Imidazo [1,2-b] pyrazole, and Thiazolo [3,2-b] dihydro-1,2-diazepine
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• 薬物代謝の研究例から(GC-MS) (バイオメディカルクロマトグラフィ--1-) -- (薬物および薬物代謝のクロマトグラフィ-)
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• pH Lowering in Liposomal Dispersiond Induced by Phospholipid Peroxidation
• Alkyl Chain Length Dependency in Hydrolysis of Liposomal Phosphatidylcholine by Dialkylphosphate
• Toxicity of Singlet Oxygen Generated Thermolytically in Escherichia coli
• Characteristic Coloration in Formation of N-1-Pyridinio Amidate and Enhancing Effect of Benzaldehydes
• A Novel Metabolite of 3,4-Methylenedioxyamphetamine (MDA) : Formation of 3-Methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline and Its Pharmacological Effect
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• COMPARISON OF THE REACTIVITIES OF [Fe_4S_4(SPh)_4]^ AND [Fe_2S_2(SPh)_4]^
• バイオオーガニックケミストリー
• REVERSIBLE ELECTROCHEMICAL REDUCTION OF 1,6,6a-TRITHIA-3,4-DIAZA-PENTALENES TO THEIR ANION RADICALS WITH THE PRODUCTION OF SUPEROXIDE
• COOXIDATION OF ENONES DURING REACTION OF SUPEROXIDE WITH ACIDIC AROMATIC AMINES
• メディシナルケミストリーを構想する
• INCREASING 5-LIPOXYGENASE INHIBITORY ACTIVITIES BY OXIDATIVE CONVERSION OF O-METHOXYPHENOLS TO CATECHOLS USING A Cu^ - ASCORBIC ACID - O_2 SYSTEM
• The Crystal Structure of the Bromoacetylated Dimer-A synthesized by the Reaction of Acridine with Hydroxylamine-O-sulfonic Acid
• N-Aminopyridinium誘導体の反応(第12報) : N-Aminopyridinium誘導体の求核反応(有機化学)
• Reaction of N-Aminopyridinium Derivatives. V. Syntheses of 1-(N-Methylacetamido) alkylpyridinium Salts and Their Reaction with Cyanide Ion.
• Application of Chemical P-450 Model Systems to Study Drug Metabolism. III. : Metabolism of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine
• FACILE PREPARATION OF UNSTABLE METABOLIC INTERMEDIATES : EPOXIDE(S) OF PYRAZOLO[1,5-a]PYRIDINE DERIVATIVES BY THE CYTOCHROME P-450 CHEMICAL MODEL
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• o_2-cu^-ASCORBIC ACID : A NOVEL OXIDATION SYSTEM FOR THE HIGHLY SELECTIVE O-CEALKYLATION OF 2-ALKOXYPHENOLS
• Epoxidation of Olefins by Superoxide in the Presence of Acyl Halide
• N-Aminopyridinium誘導体の反応(第10報) : Pyridine N-Arylimine誘導体のニトロ化および過酸化水素による酸化反応
• N-Aminopyridinium誘導体の反応(第9報) : Pyridine N-Arylimine誘導体の合成
• 2-オキサゾロン骨格の脱離能を利用した試薬類
• チトクロムP-450をモデルとした反応
• バイオサイエンスと有機合成化学との関わり
• Reaction of N-Aminopyridinium Derivatives. VI. Properties of s-Triazolo [1,5-α] pyridine Ring.
• N-Aminopyridinium誘導体の反応(第14報)Pyrazolo-diazine類の反応
• Application of Chemical P450 Model Systems to Studies on Drug Metabolism. I. Phencyclidine : A Multi-functional Model Substrate
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• Reaction of N-Aminopyridinium Derivatives. XIII. Syntheses of Pyrazolodiazines by Cyclization of N-Aminodiazinium Salts
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• ス-パ-オキシドジスムタ-ゼの活性中心構造とス-パ-オキシドジスムタ-ゼ作用を有する有機金属錯体
• Reactivity of [Fe(SAr)_4]^ (n=1 or 2) : Synthetic Model Complexes for Iron-Sulfur Protein, Rubredoxin
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• (2) 薬学の立場から(1. 大学の立場から)
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• 溺れる者酸素をつかむ(酸素と私のかかわりあい)
• 部会制度導入による学会の活性化から(日本薬学会"サテライト学会"の設立の可能性とその方向)
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• OXIDIZED RUBREDOXIN MODEL. NOVEL SYNTHESIS BY LIGAND-SUBSTITUTION WITH DISULFIDE
• まず国際感覚豊かな学会運営のベテラン養成から(薬学会の国際交流についての提言)

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