Studies on the Oxidation of 5H-N-Substituted Dibenz[b, f]azepines. III. : Oxidative Metabolism by Rat Liver Microsomes

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概要

• 論文の詳細を見る

• The metabolism of various 5H-N-substituted dibenz[b, f]azepines (1a-e) by rat liver microsomal fractions was investigated. 5H-N-Acyldibenz[b, f]azepines (1a-c) were metabolized to 5H-N-acyldibenz[b, f]azepine 10,11-oxides (2a-c), while 5H-N-alkykibenz[b, f]azepines (1d, e) were metabolized to N-alkyl-9(10H)-acridones (5d, e). 5H-N-Acyl-10,11-dihydro-trans-10,11-dihydroxydibenz[b, f]azepine (3b) was additonally detected as a metabolite of 5H-N-acyldibens[b, f]azepine 10,11-oxide (2b).The conditions for the enzymatic formation of these metabolites are discussed.

• 社団法人日本薬学会の論文
• 1986-06-25

著者

• 広部 雅昭

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 宮田 直樹

  National Institute Of Hygienic Sciences University Of Tokyo

• 大田 富夫

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 宮田 直樹

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 大田 富夫

  Tokyo Research Laboratories Kowa Co. Ltd.

• 広部 雅昭

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 広部 雅昭

  東京大学薬学部:文部省

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