Synthesis, Chemical Properties and Mutagenicity of 1,6- and 3,6-Dinitrobenzo[a]pyrenes
スポンサーリンク
概要
- 論文の詳細を見る
Nitration of benzo[a]pyrene (BaP) with HNO_3 (d=1.38) produced a mixture of dinitroBaPs (1,6- and 3,6-isomers) and mononitroBaPs (1-, 3- and 6-isomers). Pure 1,6-dinitroBaP and 3,6-dinitroBaP were obtained by the reduction of the dinitroBaPs mixture with NaSH to yield the separable products 1-amino-6-nitroBaP and 3-amino-6-nitroBaP, followed by conversion to dinitroBaPs via the the diazonium salts. The half-wave potentials (E_<1/2>) corresponding to the one-electron reduction of dinitroBaPs were measured and the relationship of these values to the mutagenicity is discussed.
- 公益社団法人日本薬学会の論文
- 1990-11-25
著者
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宮田 直樹
名古屋市立大学
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宮田 直樹
National Institute Of Hygienic Sciences University Of Tokyo
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神谷 庄造
National Institute of Hygienic Sciences, University of Tokyo
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松井 恵子
National Institute Of Hygienic Sciences
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福原 潔
National Institute of Hygienic Sciences
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松井 道子
National Institute of Hygienic Sciences
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石館 基
National Institute of Hygienic Sciences
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神谷 庄造
National Institute Of Hygienic Sciences
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