Nitrosation of 1,3-Diarylureas with Nitrosyl Chloride, Dinitrogen Trioxide and Dinitrogen Tetroxide in Dimethylformamide

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概要

• 論文の詳細を見る

• Nitrosation of 1,3-diarylureas (Ia-f) with nitrosyl chloride or dinitrogen trioxide in dimethylformamide gave 1,3-diaryl-1-nitrosoureas (IIa-f) in 59-96% yields, and nitrosation of 1,3-diarylureas (Ia, c-f) with dinitrogen tetroxide also gave 1,3-diaryl-1-nitrosoureas (IIa, c-f) in 75-91% yields. However, nitrosation of 1,3-bis (4-methoxyphenyl) urea (Ib) with dinitrogen tetroxide in dimethylformamide resulted in the formation of 1-(4-methoxy-2-nitrophenyl)-3-(4-methoxyphenyl) urea (III) in 60% yield, and nitrosation with a large excess of dinitrogen tetroxide gave 1,3-bis (4-methoxy-2-nitrophenyl) urea (IV) in 42% yield.

• 公益社団法人日本薬学会の論文
• 1983-01-25

著者

• 宮原 誠

  National Institute of Hygienic Sciences, University of Tokyo

• 神谷 庄造

  National Institute of Hygienic Sciences, University of Tokyo

• 宮原 誠

  国立医薬品食品衛生研究所 食品部

• 宮原 誠

  National Institute Of Hygienic Sciences

• 中舘 正弘

  National Institute of Hygienic Sciences

• 神谷 庄造

  National Institute Of Hygienic Sciences

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