The Mannich Reaction of 3,6-Dimethyl-5-hydroxypyridazine 1-Oxide
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3,6-Dimethyl-5-hydroxypyridazine 1-oxide (IV) reacted with formalin and a secondary amine such as pyrrolidine, piperidine, morpholine or 2,2'-dihydroxydiethylamine to give the corresponding 3,6-dimethyl-4-alkylaminomethyl-5-hydroxypyridazine 1-oxides (VIa-d). Bromination of this compound with bromine gave 3,6-dimethyl-4-bromo-5-hydroxypyridazine 1-oxide.
- 公益社団法人日本薬学会の論文
- 1975-04-25
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